Transcription Factor

						

			
Accessions: BCL11B (HT-SELEX2 May2017)

			
Names: BCL11B, ENSG00000127152
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]
Notes: TF family: Znf_C2H2 experiment: HT-SELEX Hamming distance: 1 cycle: 4, TF family: Znf_C2H2 experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 4
Length: 693
Pfam Domains:   228-249 Zinc finger, C2H2 type
  229-249 C2H2-type zinc finger
  241-264 Zinc-finger double domain
  255-277 C2H2-type zinc finger
  255-277 Zinc finger, C2H2 type
  597-618 Zinc finger, C2H2 type
  598-618 C2H2-type zinc finger
  610-634 Zinc-finger double domain
  624-646 Zinc finger, C2H2 type
  624-646 C2H2-type zinc finger
  654-677 C2H2-type zinc finger
  654-677 Zinc finger, C2H2 type
Sequence: 
(in bold interface residues)		   1 QTEAPFGCQCQLSGKDEPSSYICTTCKQPFNSAWFLLQHAQNTHGFRIYLEPGPASSSLT   60
  61 PRLTIPPPLGPEAVAQSPLMNFLGDSNPFNLLRMTGPILRDHPGFGEGRLPGTPPLFSPP  120
 121 PRHHLDPHRLSAEEMGLVAQHPSAFDRVMRLNPMAIDSPAMDFSRRLRELAGNSSTPPPV  180
 181 SPGRGNPMHRLLNPFQPSPKSPFLSTPPLPPMPPGGTPPPQPPAKSKSCEFCGKTFKFQS  240
 241 NLIVHRRSHTGEKPYKCQLCDHACSQASKLKRHMKTHMHKAGSLAGRSDDGLSAASSPEP  300
 301 GTSELAGEGLKAADGDFRHHESDPSLGHEPEEEDEEEEEEEEELLLENESRPESSFSMDS  360
 361 ELSRNRENGGGGVPGVPGAGGGAAKALADEKALVLGKVMENVGLGALPQYGELLADKQKR  420
 421 GAFLKRAAGGGDAGDDDDAGGCGDAGAGGAVNGRGGGFAPGTEPFPGLFPRKPAPLPSPG  480
 481 LNSAAKRIKVEKDLELPPAALIPSENVYSQWLVGYAASRHFMKDPFLGFTDARQSPFATS  540
 541 SEHSSENGSLRFSTPPGDLLDGGLSGRSGTASGGSTPHLGGPGPGRPSSKEGRRSDTCEY  600
 601 CGKVFKNCSNLTVHRRSHTGERPYKCELCNYACAQSSKLTRHMKTHGQIGKEVYRCDICQ  660
 661 MPFSVYSTLEKHMKKWHGEHLLTNDVKIEQAER
Interface Residues: 237, 238, 239, 240, 241, 244, 245, 266, 267, 268, 269, 270, 272, 273, 580, 582, 585, 606, 607, 608, 609, 610, 612, 613, 615, 616, 619, 634, 635, 636, 637, 638, 639, 640, 641, 642, 645, 664, 665, 666, 667, 668, 669, 670, 671, 675
3D-footprint Homologues: 7y3l_A, 8cuc_F, 8gn3_A, 5kl3_A, 4m9v_C, 7eyi_G, 5v3j_F, 7n5w_A, 3uk3_C, 1tf3_A, 6jnm_A, 5k5l_F, 8ssu_A, 4x9j_A, 1llm_D, 6blw_A, 5kkq_D, 1ubd_C, 6u9q_A, 5ei9_F, 1mey_C, 7ysf_A, 1f2i_J, 6wmi_A, 2kmk_A, 8ssq_A, 7w1m_H, 5und_A, 2gli_A, 1g2f_F, 8h9h_G, 2lt7_A, 2i13_A, 7y3m_I, 6e94_A, 6a57_A, 2jpa_A, 1tf6_A, 6ml4_A, 2wbs_A, 5yel_A, 7txc_E, 2drp_D, 5yj3_D, 5k5i_A
Binding Motifs: BCL11B_2 GTGAACGcwrwwgCTACAC
BCL11B_methyl_1 GTGAACGyyrmhvCTACAC
			
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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