Transcription Factor

Accessions: O70218 (JASPAR 2024)
Names: HMX1_MOUSE, Homeobox protein H6, Homeobox protein HMX1
Organisms: Mus musculus
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Length: 332
Pfam Domains: 192-248 Homeobox domain
Sequence:
(in bold interface residues)
1 MPDELTEPGRATPARASSFLIENLLAAEAKGAGRSTQGDGVREEEEEDDDDPEDEDPEQA 60
61 RRRLQRRRQQRAGSGPGGEARARALGLGPRPPPGPGPPFALGCGGTTRWYPRVHGGYGGG 120
121 LSPDTSDRDSPETGEEMGRAESAWPRCPGPGTVPREVTTQGPATGGEEAAELAEAPAVAA 180
181 AATGEARGGRRKKTRTVFSRSQVFQLESTFDLKRYLSSAERAGLAASLQLTETQVKIWFQ 240
241 NRRNKWKRQLAAELEAASLSPPGAQRLVRVPVLYHESPPAAAGPALPFPLAPPAPAPPPP 300
301 LLGFSGALAYPLAAFPAAASVPFLRAQMPGLV
Interface Residues: 190, 191, 192, 193, 194, 195, 233, 234, 236, 237, 240, 241, 244, 245, 248
3D-footprint Homologues: 5zfz_A, 1puf_A, 4j19_B, 1fjl_B, 2h1k_B, 1ig7_A, 3cmy_A, 6a8r_A, 2lkx_A, 6m3d_C, 1jgg_B, 3lnq_A, 1nk2_P, 1zq3_P, 6es3_K, 7q3o_C, 2ld5_A, 4xrs_G, 3a01_E, 1b72_A, 4cyc_A, 5flv_I, 2hdd_A, 5zjt_E, 2r5y_A, 7psx_B, 2hos_A, 5jlw_D, 3rkq_B, 1le8_A, 7xrc_C, 1e3o_C, 2xsd_C, 1au7_A, 1o4x_A, 1mnm_C, 1du0_A, 1puf_B, 5hod_A, 4qtr_D, 1k61_B
Binding Motifs: MA0896.1 / PH0041.1 msvAGCAATTAAwgvwt
MA0896.2 AGCAATTAA
Publications: Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed]

Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.