Transcription Factor
| Accessions: | T144613_1.02 (CISBP 1.02), P43680 (JASPAR 2024) |
| Names: | Sox18, T144613_1.02;, SOX18_MOUSE |
| Organisms: | Mus musculus |
| Libraries: | CISBP 1.02 1, JASPAR 2024 2 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P43680 |
| Notes: | experiment type:PBM, family:Sox |
| Length: | 377 |
| Pfam Domains: | 79-147 HMG (high mobility group) box 80-139 Domain of unknown function (DUF1898) 187-375 Sox C-terminal transactivation domain |
| Sequence: (in bold interface residues) | 1 MQRSPPGYGAQDDPPSRRDCAWAPGIGAAAEARGLPVTNVSPTSPASPSSLPRSPPRSPE 60 61 SGRYGFGRGERQTADELRIRRPMNAFMVWAKDERKRLAQQNPDLHNAVLSKMLGKAWKEL 120 121 NTAEKRPFVEEAERLRVQHLRDHPNYKYRPRRKKQARKVRRLEPGLLLPGLVQPSAPPEA 180 181 FAAASGSARSFRELPTLGAEFDGLGLPTPERSPLDGLEPGEASFFPPPLAPEDCALRAFR 240 241 APYAPELARDPSFCYGAPLAEALRTAPPAAPLAGLYYGTLGTPGPFPNPLSPPPESPSLE 300 301 GTEQLEPTADLWADVDLTEFDQYLNCSRTRPDATTLPYHVALAKLGPRAMSCPEESSLIS 360 361 ALSDASSAVYYSACISG |
| Interface Residues: | 81, 84, 86, 87, 90, 94, 105, 106, 107, 110, 148, 150, 152, 155, 176, 181, 182, 185, 206 |
| 3D-footprint Homologues: | 4s2q_D, 1j5n_A, 2lef_A, 4y60_C, 1o4x_B, 3f27_D, 6jrp_D, 1qrv_A, 3u2b_C, 7m5w_A, 2gzk_A, 1hry_A |
| Binding Motifs: | PB0067.1 twyhATTGTTbtmamw PB0171.1 gkrsyraATtyrwdhm M1593_1.02 ATTgwtyt |
| Publications: | Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed] |
| Related annotations: | PaperBLAST |
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