Transcription Factor
| Accessions: | T049218_1.02 (CISBP 1.02), Q99LI5 (JASPAR 2024) |
| Names: | T049218_1.02;, Zfp281, ZN281_MOUSE |
| Organisms: | Mus musculus |
| Libraries: | CISBP 1.02 1, JASPAR 2024 2 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q99LI5 |
| Notes: | experiment type:PBM, family:C2H2 ZF |
| Length: | 893 |
| Pfam Domains: | 258-280 C2H2-type zinc finger 272-295 Zinc-finger double domain 286-308 C2H2-type zinc finger 286-308 Zinc finger, C2H2 type 301-323 Zinc-finger double domain 316-336 C2H2-type zinc finger 329-352 Zinc-finger double domain 342-364 Zinc finger, C2H2 type |
| Sequence: (in bold interface residues) | 1 MKIGSGFLSGGGGPSSSGGSGSGGSSGSASGGSGGGRRAEMEPTFPQSMVMFNHRLPPVT 60 61 SFTRPAGTAAPPPQCVLSSSTSAAPAAEPPPPPAPDMTFKKEPAASAAAFPSQRTSWGFL 120 121 QSLVSIKQEKPADPEEQPSHHHHHHHHYGGLFAGAEERSPGLGGGEGGSHGVIQDLSLLH 180 181 QHAQQQPAQHHRDVLLSSGSRTDEHGNQEPKQDANVKKAKRPKPESQGIKAKRKPSASSK 240 241 PLVGEGEGAVLSPSQKPHICDHCSAAFRSSYHLRRHVLIHTGERPFQCSQCSMGFIQKYL 300 301 LQRHEKIHSREKPFGCDQCSMKFIQKYHMERHKRTHSGEKPYKCDTCQQYFSRTDRLLKH 360 361 RRTCGEAIAKGAASAEPGSSNHNSMGNLAVLSQGNTSSSRRKSKSKSIAIENKEHKTGKT 420 421 NESQMSNNINMQSYSVEMPTVSTSGSIIGTGIDELQKRVPKLIFKKGSRKNADKSYLNFV 480 481 SPLPDVVGQKSLSGKPGGSLGIVSNNSVETISLLQSTSGKQGPISSNYDDAMQFSKKRRY 540 541 LPTASSNSAFSINVGHMVSQQSVIQSAGVSVLDNEAPLSLIDSSALNAEIKSCHDKSGIP 600 601 DEVLQSILDQYSGKSETQKEDPFNLTEPRVDLHTSGEHSELVQEENLSPGTQTPSNDKTS 660 661 MLQEYSKYLQQAFEKSTNAGFTLGHGFQFVSLSSPLHNHTLFPEKQIYTTSPLECGFGQS 720 721 VTSVLPSSLPKPPFGMLFGSQPGLYLSALDATHQQLTPSQELDDLIDSQKNLETSSAFQS 780 781 SSQKLTSQKEQQKNLESSTSFQIPSQELASQIDPQKDIEPRTTYQIENFAQAFGSQFKSG 840 841 SRVPMTFITNSNGEVDHRVRTSVSDFSGYTNMMSDVSEPCSTRVKTPTSQSYR |
| Interface Residues: | 254, 255, 268, 269, 270, 271, 272, 274, 275, 276, 277, 278, 279, 281, 286, 295, 296, 297, 298, 299, 300, 301, 302, 303, 304, 307, 319, 322, 324, 325, 326, 327, 328, 330, 331, 348, 350, 353, 354, 355, 356, 357, 358, 359, 370, 372 |
| 3D-footprint Homologues: | 1yuj_A, 7w1m_H, 5k5l_F, 5v3j_F, 7n5w_A, 5yel_A, 1tf3_A, 3uk3_C, 1g2f_F, 5k5i_A, 8ssq_A, 1tf6_A, 2gli_A, 8ssu_A, 6ml4_A, 8gn3_A, 5kkq_D, 6u9q_A, 5ei9_F, 4m9v_C, 7eyi_G, 8h9h_G, 6wmi_A, 2lt7_A, 2i13_A, 7y3m_I, 6e94_A, 7ysf_A, 2jpa_A, 1ubd_C, 2kmk_A, 6jnm_A, 7y3l_A, 5yj3_D, 5und_A, 4x9j_A, 1mey_C, 6blw_A, 2wbs_A, 5kl3_A, 6a57_A, 8cuc_F, 1llm_D, 1f2i_J, 7txc_E, 2drp_D |
| Binding Motifs: | PB0097.1 tcmCCmyCCCCCmyc PB0201.1 akkwkaCCCCCAwtwwr M0420_1.02 dkGGGGGwkg MA1630.1 ggTGGGGGAgG |
| Binding Sites: | MA1630.1.1 / MA1630.1.4 MA1630.1.10 / MA1630.1.7 MA1630.1.11 / MA1630.1.2 / MA1630.1.9 MA1630.1.12 MA1630.1.13 / MA1630.1.14 MA1630.1.15 / MA1630.1.16 / MA1630.1.17 / MA1630.1.18 MA1630.1.19 MA1630.1.20 MA1630.1.3 MA1630.1.5 MA1630.1.6 MA1630.1.8 |
| Publications: | Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed] |
| Related annotations: | PaperBLAST |
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