Transcription Factor
| Accessions: | FIGLA_DBD (HumanTF 1.0), FIGLA_TF2 (HumanTF2 1.0), FIGLA (HT-SELEX2 May2017) |
| Names: | bHLHc8, Class C basic helix-loop-helix protein 8, Factor in the germline alpha, FIGalpha, FIGLA, FIGLA_HUMAN, Folliculogenesis-specific basic helix-loop-helix protein, Transcription factor FIGa, bHLHb21, Class B basic helix-loop-helix protein 21, Immunoglobulin enhancer-binding factor E12/E47, Immunoglobulin transcription factor 1, Kappa-E2-binding factor, TCF-3, TFE2_HUMAN, Transcription factor 3, Transcription factor E2-alpha, Transcription factor ITF-1, ENSG00000183733 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HumanTF2 1.0 2, HT-SELEX2 May2017 3 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] 3 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Uniprot: | Q6QHK4 |
| Notes: | Ensembl ID: ENSG00000183733; DNA-binding domain sequence; TF family: bHLH; Clone source: Gene synthesis, Ensembl ID: ENSG00000183733; Construct type: TF2(3xFLAG); TF family: bHLH; Clone source: Jolma et al. 2013, TF family: bHLH experiment: HT-SELEX Hamming distance: 1 cycle: 2, TF family: bHLH experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 2 |
| Length: | 103 |
| Pfam Domains: | 28-79 Helix-loop-helix DNA-binding domain |
| Sequence: (in bold interface residues) | 1 QLAAVCRLKRLPSGGYSSTENLQLVLERRRVANAKERERIKNLNRGFARLKALVPFLPQS 60 61 RKPSKVDILKGATEYIQVLSDLLEGAKDSKKQDPDEQSYSNNS |
| Interface Residues: | 29, 31, 32, 33, 35, 36, 37, 38, 39, 40, 43, 44, 46, 63, 65 |
| 3D-footprint Homologues: | 7z5k_B, 2ypa_A, 1an4_A, 5i50_B, 5eyo_A, 6od3_F, 7d8t_A, 2ypa_B, 2ql2_D, 5gnj_I, 4zpk_A, 7ssa_L, 7f2f_B, 6g1l_A |
| Binding Motifs: | FIGLA_DBD wmCACCTGkw CLOCK_FIGLA_1 sCAssTGkyvbywaraCRCRTGy CLOCK_FIGLA_2 cCAssTGkygymmsrdrCACGTGs ERF_FIGLA rcCGGAwrCAssTGky ETV2_FIGLA_1 rsCGGAArCAGsTGgd ETV2_FIGLA_2 rvCAssTGbtrdacCGGAwgyg ETV5_FIGLA rgmGGAArCAGGTGg FLI1_FIGLA rsmGGAwrCAssTGb GCM1_FIGLA_1 CAssTGsaCCCgCAy GCM1_FIGLA_2 CAssTGkkrbkkkrksrTGcGGG GCM1_FIGLA_2_3 CAssTGkkgsgkkggrTGcGGG GCM1_FIGLA_2_3_4 CAssTGkdrbgkgrTGcGGG GCM1_FIGLA_2_3_4_5 CAssTGkkgggsrTGcGGG GCM1_FIGLA_2_3_4_5_6 CAssTGkaamtaCCmgCAy GCM1_FIGLA_2_3_4_5_6_7 CAssTGkkcsmgrskcATGCGGG GCM1_FIGLA_2_3_4_5_6_7_8 CASsTGykmkkrkvrTGCGGG GCM1_FIGLA_2_3_4_5_6_7_8_9 CAssTGkkgbkkbaTRCGGG GCM1_FIGLA_2_3_4_5_6_7_8_9_10 CAssTGkhgbkrrTRcGGG GCM2_FIGLA_1 aTrCGGGtmCAssTG GCM2_FIGLA_2 mCAssTGkdwyswbkATGCGGG HOXD12_FIGLA gymrTwAaaakmCAssTGk MYBL1_FIGLA_1 mCAssTGkkrvbgrcsGTTr MYBL1_FIGLA_2 mCAssTGgtsskyrrcsGTTr MYBL1_FIGLA_2_3 vCAssTGgyrsrdkrrcsGTyr MYBL1_FIGLA_2_3_4 mCAssTGkwvcmgyAACsGyc MYBL1_FIGLA_2_3_4_5 mCAssTGgrvksyaACsGty PITX1_FIGLA TAATCCsywmCAssTG RFX3_FIGLA_1 GTTgCyatGgcracgsmmCAssTG RFX3_FIGLA_2 wrGcAACgsmmCAssTGka TEAD4_FIGLA_1 GGwATKymCAssTG TEAD4_FIGLA_2 GGwATGyvCAssTG TEAD4_FIGLA_2_3 CATwCCacgvhatsymCAssTGs FIGLA_2 mmCACCTGb FIGLA_methyl_1 wmCACCTGk |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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