Transcription Factor
| Accessions: | MYB_HUMAN (HOCOMOCO 10), P10242 (JASPAR 2024) |
| Names: | MYB_HUMAN, Proto-oncogene c-Myb, Transcriptional activator Myb |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P10242 |
| Length: | 640 |
| Pfam Domains: | 40-86 Myb-like DNA-binding domain 43-103 Myb-like DNA-binding domain 92-138 Myb-like DNA-binding domain 95-152 Myb-like DNA-binding domain 145-188 Myb-like DNA-binding domain 147-201 Myb-like DNA-binding domain 266-313 LMSTEN motif 401-566 C-myb, C-terminal |
| Sequence: (in bold interface residues) | 1 MARRPRHSIYSSDEDDEDFEMCDHDYDGLLPKSGKRHLGKTRWTREEDEKLKKLVEQNGT 60 61 DDWKVIANYLPNRTDVQCQHRWQKVLNPELIKGPWTKEEDQRVIELVQKYGPKRWSVIAK 120 121 HLKGRIGKQCRERWHNHLNPEVKKTSWTEEEDRIIYQAHKRLGNRWAEIAKLLPGRTDNA 180 181 IKNHWNSTMRRKVEQEGYLQESSKASQPAVATSFQKNSHLMGFAQAPPTAQLPATGQPTV 240 241 NNDYSYYHISEAQNVSSHVPYPVALHVNIVNVPQPAAAAIQRHYNDEDPEKEKRIKELEL 300 301 LLMSTENELKGQQVLPTQNHTCSYPGWHSTTIADHTRPHGDSAPVSCLGEHHSTPSLPAD 360 361 PGSLPEESASPARCMIVHQGTILDNVKNLLEFAETLQFIDSFLNTSSNHENSDLEMPSLT 420 421 STPLIGHKLTVTTPFHRDQTVKTQKENTVFRTPAIKRSILESSPRTPTPFKHALAAQEIK 480 481 YGPLKMLPQTPSHLVEDLQDVIKQESDESGIVAEFQENGPPLLKKIKQEVESPTDKSGNF 540 541 FCSHHWEGDSLNTQLFTQTSPVADAPNILTSSVLMAPASEDEDNVLKAFTVPKNRSLASP 600 601 LQPCSSTWEPASCGKMEEQMTSSSQARKYVNAFSARTLVM |
| Interface Residues: | 40, 75, 76, 77, 79, 80, 83, 84, 85, 126, 127, 128, 129, 131, 132, 136, 137, 164, 173, 178, 179, 182, 183, 184, 186, 187, 188, 191 |
| 3D-footprint Homologues: | 1w0t_A, 1ign_A, 3osg_A, 7c4r_A, 1vfc_A, 5eyb_B, 7xur_A, 2kdz_A, 3zqc_A, 6kks_A, 1mse_C, 7el3_B |
| Binding Motifs: | MYB_HUMAN.H10MO.C|M01342 CmGTTrr MA0100.3 mbCAACTGhm MA0100.4 CAACTG |
| Binding Sites: | MA0100.3.1 MA0100.3.10 MA0100.3.11 MA0100.3.12 MA0100.3.13 MA0100.3.14 MA0100.3.15 MA0100.3.16 MA0100.3.17 MA0100.3.18 MA0100.3.19 MA0100.3.2 MA0100.3.20 MA0100.3.3 MA0100.3.4 MA0100.3.5 MA0100.3.6 MA0100.3.7 MA0100.3.8 MA0100.3.9 MA0100.4.1 / MA0100.4.10 / MA0100.4.11 / MA0100.4.13 / MA0100.4.14 / MA0100.4.15 / MA0100.4.16 / MA0100.4.17 / MA0100.4.18 / MA0100.4.19 / MA0100.4.2 / MA0100.4.20 / MA0100.4.3 / MA0100.4.4 / MA0100.4.5 / MA0100.4.6 / MA0100.4.7 / MA0100.4.9 MA0100.4.12 MA0100.4.8 |
| Publications: | Frampton J, Kouzarides T, Döderlein G, Graf T, Weston K. Influence of the v-Myb transactivation domain on the oncoprotein's transformation specificity. The EMBO journal 12:1333-41 (1993). [Pubmed] |
| Related annotations: | PaperBLAST |
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