Transcription Factor

Accessions: KLF4_MOUSE (HOCOMOCO 10), Q60793 (JASPAR 2024)
Names: Epithelial zinc finger protein EZF, Gut-enriched krueppel-like factor, KLF4_MOUSE, Krueppel-like factor 4
Organisms: Mus musculus
Libraries: HOCOMOCO 10 1, JASPAR 2024 2
1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Length: 483
Pfam Domains: 400-424 C2H2-type zinc finger
400-424 Zinc finger, C2H2 type
416-438 Zinc-finger double domain
430-454 C2H2-type zinc finger
430-454 Zinc finger, C2H2 type
447-471 Zinc-finger double domain
460-482 C2H2-type zinc finger
460-482 Zinc finger, C2H2 type
Sequence:
(in bold interface residues)
1 MRQPPGESDMAVSDALLPSFSTFASGPAGREKTLRPAGAPTNRWREELSHMKRLPPLPGR 60
61 PYDLAATVATDLESGGAGAACSSNNPALLARRETEEFNDLLDLDFILSNSLTHQESVAAT 120
121 VTTSASASSSSSPASSGPASAPSTCSFSYPIRAGGDPGVAASNTGGGLLYSRESAPPPTA 180
181 PFNLADINDVSPSGGFVAELLRPELDPVYIPPQQPQPPGGGLMGKFVLKASLTTPGSEYS 240
241 SPSVISVSKGSPDGSHPVVVAPYSGGPPRMCPKIKQEAVPSCTVSRSLEAHLSAGPQLSN 300
301 GHRPNTHDFPLGRQLPTRTTPTLSPEELLNSRDCHPGLPLPPGFHPHPGPNYPPFLPDQM 360
361 QSQVPSLHYQELMPPGSCLPEEPKPKRGRRSWPRKRTATHTCDYAGCGKTYTKSSHLKAH 420
421 LRTHTGEKPYHCDWDGCGWKFARSDELTRHYRKHTGHRPFQCQKCDRAFSRSDHLALHMK 480
481 RHF
Interface Residues: 412, 413, 414, 415, 416, 418, 419, 421, 422, 425, 441, 442, 443, 444, 445, 446, 448, 449, 450, 453, 470, 471, 472, 473, 474, 475, 476, 477, 478, 481
3D-footprint Homologues: 3uk3_C, 1tf3_A, 6jnm_A, 8cuc_F, 6ml4_A, 7n5w_A, 6blw_A, 5kkq_D, 1ubd_C, 6u9q_A, 5ei9_F, 1mey_C, 5kl3_A, 7ysf_A, 6wmi_A, 5k5i_A, 2kmk_A, 8ssq_A, 7w1m_H, 5und_A, 2gli_A, 1g2f_F, 7eyi_G, 8ssu_A, 1tf6_A, 2i13_A, 1llm_D, 8h9h_G, 5v3j_F, 7y3m_I, 6e94_A, 2lt7_A, 6a57_A, 2jpa_A, 8gn3_A, 7y3l_A, 2wbs_A, 5yel_A, 7txc_E, 2drp_D, 1f2i_J, 5k5l_F, 4x9j_A, 4m9v_C, 5yj3_D
Binding Motifs: KLF4_MOUSE.H10MO.C|M01188 wGGGyGkGGycs
MA0039.1 wrrrrrArrG
MA0039.2 wGGGyGkGGc
Binding Sites: MA0039.2.1
MA0039.2.10
MA0039.2.11
MA0039.2.12
MA0039.2.13
MA0039.2.14
MA0039.2.15
MA0039.2.16
MA0039.2.17
MA0039.2.18
MA0039.2.19
MA0039.2.2
MA0039.2.20
MA0039.2.3
MA0039.2.4
MA0039.2.5
MA0039.2.6
MA0039.2.7
MA0039.2.8
MA0039.2.9
Publications: Chen X, Xu H, Yuan P, Fang F, Huss M, Vega V.B, Wong E, Orlov Y.L, Zhang W, Jiang J, Loh Y.H, Yeo H.C, Yeo Z.X, Narang V, Govindarajan K.R, Leong B, Shahab A, Ruan Y, Bourque G, Sung W.K, Clarke N.D, Wei C.L, Ng H.H. Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell 133:1106-17 (2008). [Pubmed]

Shields J.M, Yang V.W. Identification of the DNA sequence that interacts with the gut-enriched Krüppel-like factor. Nucleic acids research 26:796-802 (1998). [Pubmed]
Related annotations: PaperBLAST

Disclaimer and license

These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.