Transcription Factor
Accessions: | KLF4_MOUSE (HOCOMOCO 10), Q60793 (JASPAR 2024) |
Names: | Epithelial zinc finger protein EZF, Gut-enriched krueppel-like factor, KLF4_MOUSE, Krueppel-like factor 4 |
Organisms: | Mus musculus |
Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
Length: | 483 |
Pfam Domains: | 400-424 C2H2-type zinc finger 400-424 Zinc finger, C2H2 type 416-438 Zinc-finger double domain 430-454 C2H2-type zinc finger 430-454 Zinc finger, C2H2 type 447-471 Zinc-finger double domain 460-482 C2H2-type zinc finger 460-482 Zinc finger, C2H2 type |
Sequence: (in bold interface residues) | 1 MRQPPGESDMAVSDALLPSFSTFASGPAGREKTLRPAGAPTNRWREELSHMKRLPPLPGR 60 61 PYDLAATVATDLESGGAGAACSSNNPALLARRETEEFNDLLDLDFILSNSLTHQESVAAT 120 121 VTTSASASSSSSPASSGPASAPSTCSFSYPIRAGGDPGVAASNTGGGLLYSRESAPPPTA 180 181 PFNLADINDVSPSGGFVAELLRPELDPVYIPPQQPQPPGGGLMGKFVLKASLTTPGSEYS 240 241 SPSVISVSKGSPDGSHPVVVAPYSGGPPRMCPKIKQEAVPSCTVSRSLEAHLSAGPQLSN 300 301 GHRPNTHDFPLGRQLPTRTTPTLSPEELLNSRDCHPGLPLPPGFHPHPGPNYPPFLPDQM 360 361 QSQVPSLHYQELMPPGSCLPEEPKPKRGRRSWPRKRTATHTCDYAGCGKTYTKSSHLKAH 420 421 LRTHTGEKPYHCDWDGCGWKFARSDELTRHYRKHTGHRPFQCQKCDRAFSRSDHLALHMK 480 481 RHF |
Interface Residues: | 412, 413, 414, 415, 416, 418, 419, 421, 422, 425, 441, 442, 443, 444, 445, 446, 448, 449, 450, 453, 470, 471, 472, 473, 474, 475, 476, 477, 478, 481 |
3D-footprint Homologues: | 3uk3_C, 1tf3_A, 6jnm_A, 8cuc_F, 6ml4_A, 7n5w_A, 6blw_A, 5kkq_D, 1ubd_C, 6u9q_A, 5ei9_F, 1mey_C, 5kl3_A, 7ysf_A, 6wmi_A, 5k5i_A, 2kmk_A, 8ssq_A, 7w1m_H, 5und_A, 2gli_A, 1g2f_F, 7eyi_G, 8ssu_A, 1tf6_A, 2i13_A, 1llm_D, 8h9h_G, 5v3j_F, 7y3m_I, 6e94_A, 2lt7_A, 6a57_A, 2jpa_A, 8gn3_A, 7y3l_A, 2wbs_A, 5yel_A, 7txc_E, 2drp_D, 1f2i_J, 5k5l_F, 4x9j_A, 4m9v_C, 5yj3_D |
Binding Motifs: | KLF4_MOUSE.H10MO.C|M01188 wGGGyGkGGycs MA0039.1 wrrrrrArrG MA0039.2 wGGGyGkGGc |
Binding Sites: | MA0039.2.1 MA0039.2.10 MA0039.2.11 MA0039.2.12 MA0039.2.13 MA0039.2.14 MA0039.2.15 MA0039.2.16 MA0039.2.17 MA0039.2.18 MA0039.2.19 MA0039.2.2 MA0039.2.20 MA0039.2.3 MA0039.2.4 MA0039.2.5 MA0039.2.6 MA0039.2.7 MA0039.2.8 MA0039.2.9 |
Publications: | Chen X, Xu H, Yuan P, Fang F, Huss M, Vega V.B, Wong E, Orlov Y.L, Zhang W, Jiang J, Loh Y.H, Yeo H.C, Yeo Z.X, Narang V, Govindarajan K.R, Leong B, Shahab A, Ruan Y, Bourque G, Sung W.K, Clarke N.D, Wei C.L, Ng H.H. Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell 133:1106-17 (2008). [Pubmed] Shields J.M, Yang V.W. Identification of the DNA sequence that interacts with the gut-enriched Krüppel-like factor. Nucleic acids research 26:796-802 (1998). [Pubmed] |
Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.