Transcription Factor
| Accessions: | bab1 (DrosophilaTF 1.1), T136827_1.02 (CISBP 1.02) |
| Names: | BAB1_DROME, bab1, T136827_1.02; |
| Organisms: | Drosophila melanogaster |
| Libraries: | DrosophilaTF 1.1 1, CISBP 1.02 2 1 Down T.A, Bergman C.M, Su J, Hubbard T.J. Large-scale discovery of promoter motifs in Drosophila melanogaster. PLoS computational biology 3:e7 (2007). [Pubmed] 2 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] |
| Uniprot: | Q9W0K7 |
| Notes: | experiment type:B1H, family:Pipsqueak |
| Length: | 977 |
| Pfam Domains: | 117-214 BTB/POZ domain 569-612 helix-turn-helix, Psq domain |
| Sequence: (in bold interface residues) | 1 MASAQAETNVGLASEQGPVAQRQRKGTGSGADSPKSNRSSPTQQEEKRIKSEDRTSPTGG 60 61 AKDEDKESQGHAVAGGGGSSPVSSPQGRSSSVASPSSSSQQFCLRWNNYQTNLTTIFDQL 120 121 LQNECFVDVTLACDGRSMKAHKMVLSACSPYFQTLLAETPCQHPIVIMRDVNWSDLKAIV 180 181 EFMYRGEINVSQDQIGPLLRIAEMLKVRGLADVTHMEAATAAAAAASSERMPSSPKESTS 240 241 TSRTEHDREREAEELLAFMQPEKKLRTSDWDPAELRLSPLERQQGRNVRKRRWPSADTIF 300 301 NPPAPPSPLSSLIAAERMELEQKERERQRDCSLMTPPPKPPMSSGSTVGATRRLETAIHA 360 361 LDMPSPAATPGPLSRSSRPHSQSPQQQQAQQQGQLPLPLPLHPHHHASPAPHPSQTAGSA 420 421 HHPASPAGDSRFPLGPAAAMAAARELSGLGPGPSAEPRLPPPPPHHHGGGGVGGGGVGGG 480 481 GAGGVGSGGGSSLADDLEIKPGIAEMIREEERAKMMENSHAWMGATGSTLAADSYQYQLQ 540 541 SMWQKCWNTNQNLMHHMRFRERGPLKSWRPETMAEAIFSVLKEGLSLSQAARKYDIPYPT 600 601 FVLYANRVHNMLGPSIDGGPDLRPKGRGRPQRILLGIWPDEHIKGVIKTVVFRDTKDIKD 660 661 ESLAAHMPPYGRHSPAFPLQDLPLSYPGASGALAGAPSSMACPNGSGPQTGVGVAGEQHM 720 721 SQETAAAVAAVAHNIRQQMQMAAVPPGLFNLPPHPGVGGGVGNVPGAAGGRASISPALSS 780 781 GSGPRHAPSPCGPAGLLPNLPPSMAVALHHQQQQQAAHHHMQQLHLQQQQAHLHHHQQQQ 840 841 QQQQQQHHQGGHQVAHKSGFGASSSSSASSSSMGQHHAPKAKSSPLRSETPRLHSPLGDL 900 901 GLDMASYKREFSPSRLFAEDLAELVGASVSSSSSSAAAATAPPERSAGAASAATGADAPS 960 961 SSSSGGIKVEPITTTSE |
| Interface Residues: | 905 |
| 3D-footprint Homologues: | 6ymg_A |
| Binding Motifs: | bab1 wawwwWTwwtkk M4757_1.02 TATwawTrTT |
| Binding Sites: | bab1_10S6-1 bab1_10S6-2 bab1_11S6-1 bab1_11S6-2 bab1_12S6 bab1_14S6-2 bab1_14S6-3 bab1_15S6 bab1_16S6-1 bab1_16S6-2 bab1_17S6-1 bab1_19S6-1 bab1_1S6-1 bab1_1S6-2 bab1_23S6-2 bab1_24S6-1 bab1_27S6-2 bab1_28S6 bab1_29S6-1 bab1_2S6-1 bab1_3S6 bab1_4S6 bab1_5S6 bab1_6S6 bab1_7S6-1 bab1_7S6-3 bab1_9S6 |
| Publications: | Lours C, Bardot O, Godt D, Laski F.A, Couderc J.L. The Drosophila melanogaster BTB proteins bric à brac bind DNA through a composite DNA binding domain containing a pipsqueak and an AT-Hook motif. Nucleic acids research 31:5389-98 (2003). [Pubmed] |
| Related annotations: | PaperBLAST |
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