Transcription Factor
| Accessions: | 2hzv_A (3D-footprint 20231221), 2hzv_B (3D-footprint 20231221), 2hzv_C (3D-footprint 20231221), 2hzv_D (3D-footprint 20231221), 2hzv_E (3D-footprint 20231221), 2hzv_F (3D-footprint 20231221), 2hzv_G (3D-footprint 20231221), 2hzv_H (3D-footprint 20231221) |
| Names: | Nickel-responsive regulator, NIKR_ECOLI |
| Organisms: | Escherichia coli, strain K12 |
| Libraries: | 3D-footprint 20231221 1 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
| Uniprot: | P0A6Z6 |
| Length: | 131 |
| Pfam Domains: | 3-41 Ribbon-helix-helix protein, copG family 54-130 NikR C terminal nickel binding domain |
| Sequence: (in bold interface residues) | 1 MQRVTITLDDDLLETLDSLSQRRGYNNRSEAIRDILRSALAQEATQQHGTQGFAVLSYVY 60 61 EHEKRDLASRIVSTQHHHHDLSVATLHVHINHDDCLEIAVLKGDMGDVQHFADDVIAQRG 120 121 VRHGHLQCLPK |
| Interface Residues: | 3, 5, 7, 10, 32, 53, 56, 65 |
| 3D-footprint Homologues: | 1b01_B, 6mrj_D, 2hzv_A, 7nyw_J, 3gxq_A, 5xvp_B |
| Binding Motifs: | 2hzv_A TCAta 2hzv_ABCD GTyTGAnnnnnnnnnnnnnnnnTCAwAC 2hzv_EFGH aGTATGAcnnnnnnnnnnnnnnnTCATAC |
| Binding Sites: | 2hzv_I / 2hzv_K 2hzv_J / 2hzv_L |
| Publications: | Schreiter E.R, Wang S.C, Zamble D.B, Drennan C.L. NikR-operator complex structure and the mechanism of repressor activation by metal ions. Proceedings of the National Academy of Sciences of the United States of America 103:13676-81 (2006). [Pubmed] |
| Related annotations: | PaperBLAST |
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