Transcription Factor
| Accessions: | PBX3_HUMAN (HOCOMOCO 10), P40426 (JASPAR 2024) |
| Names: | Homeobox protein PBX3, PBX3_HUMAN, Pre-B-cell leukemia transcription factor 3 |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 434 |
| Pfam Domains: | 42-234 PBC domain 236-295 Homeobox domain 254-292 Homeobox KN domain |
| Sequence: (in bold interface residues) | 1 MDDQSRMLQTLAGVNLAGHSVQGGMALPPPPHGHEGADGDGRKQDIGDILHQIMTITDQS 60 61 LDEAQAKKHALNCHRMKPALFSVLCEIKEKTGLSIRGAQEEDPPDPQLMRLDNMLLAEGV 120 121 SGPEKGGGSAAAAAAAAASGGSSDNSIEHSDYRAKLTQIRQIYHTELEKYEQACNEFTTH 180 181 VMNLLREQSRTRPISPKEIERMVGIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRR 240 241 NFSKQATEILNEYFYSHLSNPYPSEEAKEELAKKCSITVSQVSNWFGNKRIRYKKNIGKF 300 301 QEEANLYAAKTAVTAAHAVAAAVQNNQTNSPTTPNSGSSGSFNLPNSGDMFMNMQSLNGD 360 361 SYQGSQVGANVQSQVDTLRHVINQTGGYSDGLGGNSLYSPHNLNANGGWQDATTPSSVTS 420 421 PTEGPGSVHSDTSN |
| Interface Residues: | 181, 197, 198, 200, 201, 209, 215, 218, 219, 222, 236, 237, 238, 239, 240, 280, 281, 283, 284, 287, 288, 291, 292, 295 |
| 3D-footprint Homologues: | 2p7c_B, 1au7_A, 5zfz_A, 3d1n_M, 1puf_A, 1fjl_B, 2h1k_B, 6fqp_B, 6a8r_A, 3cmy_A, 6m3d_C, 3lnq_A, 2lkx_A, 1zq3_P, 1jgg_B, 2ld5_A, 5jlw_D, 4cyc_A, 7psx_B, 4j19_B, 2r5y_A, 1puf_B, 5zjt_E, 3a01_E, 2h8r_B, 1b72_A, 5hod_A, 3rkq_B, 1le8_A, 7q3o_C, 1ig7_A, 1mnm_C, 1du0_A, 2d5v_B, 1k61_B, 6es3_K, 4xrs_G, 5flv_I, 4qtr_D, 1le8_B, 6fqq_E, 4xrm_B, 2hdd_A, 2hos_A |
| Binding Motifs: | PBX3_HUMAN.H10MO.B|M01429 ykyTGATTGrytgg MA1114.1 gkbTGAGTGACAGgcrs MA1114.2 TGAGTGACAGg |
| Binding Sites: | MA1114.1.1 MA1114.1.10 MA1114.1.11 MA1114.1.12 MA1114.1.13 MA1114.1.14 MA1114.1.15 MA1114.1.16 MA1114.1.17 MA1114.1.18 MA1114.1.19 MA1114.1.2 MA1114.1.20 MA1114.1.3 MA1114.1.4 MA1114.1.5 MA1114.1.6 MA1114.1.7 MA1114.1.8 MA1114.1.9 MA1114.2.1 MA1114.2.10 MA1114.2.11 MA1114.2.12 MA1114.2.13 MA1114.2.14 MA1114.2.15 MA1114.2.16 MA1114.2.17 MA1114.2.18 / MA1114.2.19 MA1114.2.2 MA1114.2.20 MA1114.2.3 MA1114.2.4 MA1114.2.5 MA1114.2.6 MA1114.2.7 MA1114.2.8 MA1114.2.9 |
| Publications: | Shen W. F., Rozenfeld S., Kwong A., Kom ves L. G., Lawrence H. J., Largman C. HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells.. Mol. Cell. Biol. 19:3051-3061 (1999). [Pubmed] |
| Related annotations: | PaperBLAST |
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