Transcription Factor

Accessions: P43136 (JASPAR 2024)
Names: COUP transcription factor 3, COUP-TF3, EAR-2, NR2F6_MOUSE, Nuclear receptor subfamily 2 group F member 6, V-erbA-related protein 2
Organisms: Mus musculus
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: P43136
Length: 390
Pfam Domains: 56-124 Zinc finger, C4 type (two domains)
185-363 Ligand-binding domain of nuclear hormone receptor
Sequence:
(in bold interface residues)
1 MAMVTGGWGDPGGDTNGVDKAGGSYPRATEDDSASPPGATSDAEPGDEERPGLQVDCVVC 60
61 GDKSSGKHYGVFTCEGCKSFFKRSIRRNLSYTCRSNRDCQIDQHHRNQCQYCRLKKCFRV 120
121 GMRKEAVQRGRIPHALPGPAACSPPGATGVEPFTGPPVSELIAQLLRAEPYPAAGRFGGG 180
181 GAVLGIDNVCELAARLLFSTVEWARHAPFFPELPAADQVALLRLSWSELFVLNAAQAALP 240
241 LHTAPLLAAAGLHAAPMAAERAVAFMDQVRAFQEQVDKLGRLQVDAAEYGCLKAIALFTP 300
301 DACGLSDPAHVESLQEKAQVALTEYVRAQYPSQPQRFGRLLLRLPALRAVPASLISQLFF 360
361 MRLVGKTPIETLIRDMLLSGSTFNWPYGSG
Interface Residues: 65, 66, 68, 69, 75, 76, 78, 79, 82, 83, 107, 129, 131, 133
3D-footprint Homologues: 6fbq_A, 7wnh_D, 6l6q_B, 3g9m_B, 1a6y_A, 1lo1_A, 4oln_B, 2han_B, 1kb2_B, 2a66_A, 2nll_B, 1lat_A, 7xv6_B, 2ff0_A, 1dsz_A, 4umm_E, 3cbb_A, 8cef_H, 4iqr_B, 2han_A, 1hcq_E, 8hbm_B, 5krb_G, 5cbz_E, 4tnt_B, 5e69_A, 4hn5_B, 5emc_A, 7prw_B, 5cbx_B, 3g6t_A, 1r4i_A
Binding Motifs: MA0677.1 rrGGTCAAAGGTCA
MA0728.1 rAGGTCAArAGGTCA
MA0677.2 rGGTCAAAGGTCA
Publications: Liu X, Huang X, Sigmund CD. Identification of a nuclear orphan receptor (Ear2) as a negative regulator of renin gene transcription. Circ Res 92:1033-40 (2003). [Pubmed]
Related annotations: PaperBLAST

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