Transcription Factor
| Accessions: | KLF4_HUMAN (HOCOMOCO 10), O43474 (JASPAR 2024) |
| Names: | Epithelial zinc finger protein EZF, Gut-enriched krueppel-like factor, KLF4_HUMAN, Krueppel-like factor 4 |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | O43474 |
| Length: | 513 |
| Pfam Domains: | 430-454 Zinc finger, C2H2 type 430-454 C2H2-type zinc finger 446-468 Zinc-finger double domain 460-484 Zinc finger, C2H2 type 460-484 C2H2-type zinc finger 477-501 Zinc-finger double domain 490-512 Zinc finger, C2H2 type 490-512 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 MRQPPGESDMAVSDALLPSFSTFASGPAGREKTLRQAGAPNNRWREELSHMKRLPPVLPG 60 61 RPYDLAAATVATDLESGGAGAACGGSNLAPLPRRETEEFNDLLDLDFILSNSLTHPPESV 120 121 AATVSSSASASSSSSPSSSGPASAPSTCSFTYPIRAGNDPGVAPGGTGGGLLYGRESAPP 180 181 PTAPFNLADINDVSPSGGFVAELLRPELDPVYIPPQQPQPPGGGLMGKFVLKASLSAPGS 240 241 EYGSPSVISVSKGSPDGSHPVVVAPYNGGPPRTCPKIKQEAVSSCTHLGAGPPLSNGHRP 300 301 AAHDFPLGRQLPSRTTPTLGLEEVLSSRDCHPALPLPPGFHPHPGPNYPSFLPDQMQPQV 360 361 PPLHYQGQSRGFVARAGEPCVCWPHFGTHGMMLTPPSSPLELMPPGSCMPEEPKPKRGRR 420 421 SWPRKRTATHTCDYAGCGKTYTKSSHLKAHLRTHTGEKPYHCDWDGCGWKFARSDELTRH 480 481 YRKHTGHRPFQCQKCDRAFSRSDHLALHMKRHF |
| Interface Residues: | 442, 443, 444, 445, 446, 448, 449, 451, 452, 455, 471, 472, 473, 474, 475, 476, 478, 479, 480, 483, 500, 501, 502, 503, 504, 505, 506, 507, 508, 511 |
| 3D-footprint Homologues: | 1tf3_A, 6jnm_A, 8cuc_F, 6ml4_A, 7n5w_A, 3uk3_C, 7ysf_A, 6wmi_A, 5k5i_A, 2kmk_A, 8ssq_A, 7w1m_H, 5und_A, 2gli_A, 1g2f_F, 7eyi_G, 8ssu_A, 1tf6_A, 4x9j_A, 2i13_A, 1llm_D, 6blw_A, 5kkq_D, 1ubd_C, 6u9q_A, 5ei9_F, 1mey_C, 5kl3_A, 5v3j_F, 8h9h_G, 2lt7_A, 7y3m_I, 6e94_A, 6a57_A, 2jpa_A, 8gn3_A, 7y3l_A, 2drp_D, 1f2i_J, 5k5l_F, 2wbs_A, 5yel_A, 7txc_E, 4m9v_C, 5yj3_D |
| Binding Motifs: | KLF4_HUMAN.H10MO.A|M01293 dGGGyGkGGc MA0039.3 mcACACCCwsc MA0039.4 ssCCCCACCChs MA0039.5 CCCCACCC |
| Binding Sites: | MA0039.5.17 MA0039.5.10 MA0039.5.18 / MA0039.5.2 MA0039.5.1 / MA0039.5.11 / MA0039.5.12 / MA0039.5.19 / MA0039.5.3 / MA0039.5.9 MA0039.5.4 MA0039.5.6 / MA0039.5.8 MA0039.3.1 MA0039.3.10 MA0039.3.11 MA0039.3.12 MA0039.3.13 MA0039.3.14 MA0039.3.15 MA0039.3.16 MA0039.3.17 MA0039.3.18 MA0039.3.19 MA0039.3.2 MA0039.3.20 MA0039.3.3 MA0039.3.4 MA0039.3.5 MA0039.3.6 MA0039.3.7 MA0039.3.8 MA0039.3.9 MA0039.4.1 MA0039.4.10 MA0039.4.11 / MA0039.4.8 MA0039.4.12 MA0039.4.13 / MA0039.4.9 MA0039.4.10 / MA0039.4.14 MA0039.4.11 / MA0039.4.15 MA0039.4.16 MA0039.4.12 / MA0039.4.17 MA0039.4.18 MA0039.4.19 MA0039.4.1 / MA0039.4.2 MA0039.4.13 / MA0039.4.20 MA0039.4.2 / MA0039.4.3 MA0039.4.3 / MA0039.4.4 MA0039.4.5 MA0039.4.6 MA0039.4.7 MA0039.4.8 MA0039.4.7 / MA0039.4.9 MA0039.4.14 MA0039.4.15 MA0039.4.16 MA0039.4.17 MA0039.4.18 MA0039.4.19 MA0039.4.20 MA0039.4.4 MA0039.5.13 MA0039.5.14 / MA0039.5.16 MA0039.5.15 / MA0039.5.5 MA0039.5.20 MA0039.5.7 |
| Publications: | Chen X, Xu H, Yuan P, Fang F, Huss M, Vega V.B, Wong E, Orlov Y.L, Zhang W, Jiang J, Loh Y.H, Yeo H.C, Yeo Z.X, Narang V, Govindarajan K.R, Leong B, Shahab A, Ruan Y, Bourque G, Sung W.K, Clarke N.D, Wei C.L, Ng H.H. Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell 133:1106-17 (2008). [Pubmed] Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.