Transcription Factor
| Accessions: | HXA13_MOUSE (HOCOMOCO 10), Q62424 (JASPAR 2024) |
| Names: | Homeobox protein Hox-1.10, Homeobox protein Hox-A13, HXA13_MOUSE |
| Organisms: | Mus musculus |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 386 |
| Pfam Domains: | 80-133 Hox protein A13 N terminal 124-222 Hox protein A13 N terminal 321-377 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MTASVLLHPRWIEPTVMFLYDNGGGLVADELNKNMEGAAAAAAAAAAAAAAGAGGGGFPH 60 61 PAAAAAGGNFSVAAAAAAAAAAAANQCRNLMAHPAPLAPGAAAAYSSAPGEAPPSAAAAA 120 121 AAAAAAAAAAAAASSSGGPGPAGPAGAEAAKQCSPCSAAAQSSSGPAALPYGYFGSGYYP 180 181 CARMGPHPNAIKSCAQPASAAAAFADKYMDTAGPAAEEFSSRAKEFAFYHQGYAAGPYHH 240 241 HQPVPGYLDMPVVPGLGGPGESRHEPLGLPMESYQPWALPNGWNGQMYCPKEQTQPPHLW 300 301 KSTLPDVVSHPSDASSYRRGRKKRVPYTKVQLKELEREYATNKFITKDKRRRISATTNLS 360 361 ERQVTIWFQNRRVKEKKVINKLKTTS |
| Interface Residues: | 321, 322, 323, 324, 362, 363, 365, 366, 369, 370, 373, 374, 377 |
| 3D-footprint Homologues: | 2h1k_B, 5zfz_A, 1puf_A, 1ig7_A, 3cmy_A, 6a8r_A, 1fjl_B, 2lkx_A, 6m3d_C, 2p0j_A, 1jgg_B, 1nk2_P, 1zq3_P, 3lnq_A, 7q3o_C, 2ld5_A, 6es3_K, 4xrs_G, 1b72_A, 3rkq_B, 5flv_I, 3a01_E, 2hdd_A, 5zjt_E, 4cyc_A, 1puf_B, 5hod_A, 2hos_A, 2r5y_A, 7psx_B, 5jlw_D, 2xsd_C, 1le8_A, 7xrc_C, 6ryd_F, 1e3o_C, 1au7_A, 1mnm_C, 1du0_A, 4qtr_D, 1k61_B, 1o4x_A |
| Binding Motifs: | HXA13_MOUSE.H10MO.C|M01154 grTwTTATtGg PH0048.1 wwwbCTCGTAAAawtt MA0650.3 wgCCAATAAAaw MA0650.4 CCAATAAA |
| Binding Sites: | MA0650.4.6 MA0650.4.11 / MA0650.4.3 MA0650.4.20 / MA0650.4.7 MA0650.4.2 MA0650.4.1 / MA0650.4.16 MA0650.4.8 MA0650.4.15 / MA0650.4.4 MA0650.4.18 / MA0650.4.19 MA0650.4.13 / MA0650.4.14 MA0650.3.1 / MA0650.3.4 MA0650.3.10 / MA0650.3.18 MA0650.3.11 / MA0650.3.19 MA0650.3.12 MA0650.3.13 MA0650.3.14 MA0650.3.15 MA0650.3.16 MA0650.3.17 MA0650.3.18 MA0650.3.19 MA0650.3.2 / MA0650.3.5 MA0650.3.20 MA0650.3.10 / MA0650.3.3 MA0650.3.12 / MA0650.3.4 MA0650.3.13 / MA0650.3.5 MA0650.3.6 MA0650.3.14 / MA0650.3.7 MA0650.3.15 / MA0650.3.8 MA0650.3.17 / MA0650.3.9 MA0650.3.1 / MA0650.3.2 MA0650.3.11 MA0650.3.16 MA0650.3.20 MA0650.3.3 MA0650.3.6 MA0650.3.7 MA0650.3.8 MA0650.3.9 MA0650.4.10 / MA0650.4.9 MA0650.4.12 MA0650.4.17 MA0650.4.5 |
| Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] Knosp W. M., Saneyoshi C., Shou S., Bachinger H. P., Stadler H. S. Elucidation, quantitative refinement, and in vivo utilization of the HOXA13 DNA binding site.. J. Biol. Chem. 282:6843-6853 (2007). [Pubmed] |
| Related annotations: | PaperBLAST |
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