Transcription Factor
| Accessions: | NOBOX_MOUSE (HOCOMOCO 10), P70367 (JASPAR 2024), Q8VIH1 (JASPAR 2024) |
| Names: | Homeobox protein NOBOX, Homeodomain-containing protein OG-2, Newborn ovary homeobox protein, NOBOX_MOUSE, Oocyte-specific homeobox protein |
| Organisms: | Mus musculus |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P70367 |
| Length: | 527 |
| Pfam Domains: | 137-193 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MEPTEKLCKKMQGQEAGDKPRTAALETEGPLQDSALPIQDDQDKQSSLPRASLGKRPLSK 60 61 TSEELMDAGTCRVHKAPTAAACGPQSEEEGCSPPERKAESLKPSISAVPGQATAGSLNSH 120 121 EGDLKKESLEVTCQFRKKTRTLYRSDQLEELERIFQEDHYPDSDKRHEISQMVGVTPQRI 180 181 MVWFQNRRAKWRKVEKLNEKETKNGPAAPSADSSQHRSAPELLDPMPTDLEPGPVPPENI 240 241 LDVFPEPPMLLTSEQTLTPFQNNEGAERVAVTPPLLSPPPIRRANLPLPLGPVQTPQVLP 300 301 PMRDVPGSDSIYKDKAYVSWGTSIASPPTYSNLEDLGSQDYQASSQLGSFQLSQAPHLPL 360 361 FPSLQSQFPYLPPFPYPIPSSMPFLPPEDSLFSFPFGFSGDSSQDYCPGPPPGQILLQPP 420 421 AENMGTGPWSGHCLPEPPFPRPHYPQALGQPLGAEGYFPNLLPTPYALTMSKQSSLGLNG 480 481 LLEGTRVETGSSLSKMSDEQTSSSLEQPALEEVRDKNKNSHAAGAKE |
| Interface Residues: | 136, 137, 138, 139, 140, 178, 179, 181, 182, 185, 186, 189, 190, 193 |
| 3D-footprint Homologues: | 3a01_E, 4j19_B, 1ig7_A, 6a8r_A, 3cmy_A, 2h1k_B, 1puf_A, 3d1n_M, 1au7_A, 5zfz_A, 1fjl_B, 1zq3_P, 3lnq_A, 1jgg_B, 2lkx_A, 6m3d_C, 1nk2_P, 2ld5_A, 7q3o_C, 6es3_K, 1puf_B, 7psx_B, 5hod_A, 5jlw_D, 3rkq_B, 4xrs_G, 2hdd_A, 4cyc_A, 2r5y_A, 5flv_I, 3l1p_A, 2hos_A, 1b72_A, 5zjt_E, 1e3o_C, 1le8_A, 1o4x_A, 1du0_A, 4qtr_D, 8g87_X |
| Binding Motifs: | NOBOX_MOUSE.H10MO.C|M01250 hTAATTrsy MA0125.1 TAATTrsy PH0127.1 cgsryyAATTrrkways MA0125.2 TAATTr |
| Binding Sites: | MA0125.1.1 MA0125.1.10 MA0125.1.11 / MA0125.1.12 / MA0125.1.13 / MA0125.1.14 MA0125.1.15 / MA0125.1.16 MA0125.1.17 MA0125.1.18 MA0125.1.19 / MA0125.1.20 MA0125.1.2 / MA0125.1.3 / MA0125.1.4 / MA0125.1.5 / MA0125.1.6 / MA0125.1.7 / MA0125.1.8 MA0125.1.9 MA0125.2.1 / MA0125.2.11 / MA0125.2.12 / MA0125.2.13 / MA0125.2.14 / MA0125.2.19 / MA0125.2.20 MA0125.2.10 / MA0125.2.15 / MA0125.2.16 MA0125.2.17 / MA0125.2.9 MA0125.2.18 / MA0125.2.2 / MA0125.2.3 / MA0125.2.4 / MA0125.2.5 / MA0125.2.6 / MA0125.2.7 / MA0125.2.8 |
| Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] Choi Y, Rajkovic A. Characterization of NOBOX DNA binding specificity and its regulation of Gdf9 and Pou5f1 promoters. The Journal of biological chemistry 281:35747-56 (2006). [Pubmed] |
| Related annotations: | PaperBLAST |
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