Transcription Factor
| Accessions: | T084794_1.02 (CISBP 1.02), GATA4_MOUSE (HOCOMOCO 10), Q08369 (JASPAR 2024) |
| Names: | Gata4, T084794_1.02;, GATA-binding factor 4, GATA4_MOUSE, Transcription factor GATA-4 |
| Organisms: | Mus musculus |
| Libraries: | CISBP 1.02 1, HOCOMOCO 10 2, JASPAR 2024 3 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q08369 |
| Notes: | experiment type:PBM, family:GATA |
| Length: | 441 |
| Pfam Domains: | 1-207 GATA-type transcription activator, N-terminal 216-249 GATA zinc finger 270-303 GATA zinc finger |
| Sequence: (in bold interface residues) | 1 MYQSLAMAANHGPPPGAYEAGGPGAFMHSAGAASSPVYVPTPRVPSSVLGLSYLQGGGSA 60 61 AAAGTTSGGSSGAGPSGAGPGTQQGSPGWSQAGAEGAAYTPPPVSPRFSFPGTTGSLAAA 120 121 AAAAAAREAAAYGSGGGAAGAGLAGREQYGRPGFAGSYSSPYPAYMADVGASWAAAAAAS 180 181 AGPFDSPVLHSLPGRANPGRHPNLDMFDDFSEGRECVNCGAMSTPLWRRDGTGHYLCNAC 240 241 GLYHKMNGINRPLIKPQRRLSASRRVGLSCANCQTTTTTLWRRNAEGEPVCNACGLYMKL 300 301 HGVPRPLAMRKEGIQTRKRKPKNLNKSKTPAGPAGETLPPSSGASSGNSSNATSSSSSSE 360 361 EMRPIKTEPGLSSHYGHSSSMSQTFSTVSGHGPSIHPVLSALKLSPQGYASPVTQTSQAS 420 421 SKQDSWNSLVLADSHGDIITA |
| Interface Residues: | 225, 226, 228, 238, 242, 279, 280, 282, 292, 296, 297, 300, 317, 319, 320 |
| 3D-footprint Homologues: | 4hc9_A, 3vd6_C, 1gat_A, 3dfx_B, 4gat_A |
| Binding Motifs: | MA0482.1 yCTTATCTsyy M0785_1.02 cwGATwasr GATA4_MOUSE.H10MO.B|M01120 rswGATAav |
| Binding Sites: | MA0482.1.1 MA0482.1.10 MA0482.1.11 MA0482.1.12 MA0482.1.13 MA0482.1.14 MA0482.1.15 MA0482.1.16 MA0482.1.17 MA0482.1.18 MA0482.1.19 MA0482.1.2 MA0482.1.20 MA0482.1.3 MA0482.1.4 MA0482.1.5 MA0482.1.6 MA0482.1.7 MA0482.1.8 MA0482.1.9 |
| Publications: | Yamagata T, Nishida J, Sakai R, Tanaka T, Honda H, Hirano N, Mano H, Yazaki Y, Hirai H. Of the GATA-binding proteins, only GATA-4 selectively regulates the human interleukin-5 gene promoter in interleukin-5-producing cells which express multiple GATA-binding proteins. Molecular and cellular biology 15:3830-9 (1995). [Pubmed] |
| Related annotations: | PaperBLAST |
Disclaimer and license
These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.