Transcription Factor

Accessions: T081983_1.02 (CISBP 1.02), FOXA2_MOUSE (HOCOMOCO 10), P35583 (JASPAR 2024)
Names: Foxa2, T081983_1.02;, Forkhead box protein A2, FOXA2_MOUSE, Hepatocyte nuclear factor 3-beta, HNF-3-beta, HNF-3B
Organisms: Mus musculus
Libraries: CISBP 1.02 1, HOCOMOCO 10 2, JASPAR 2024 3
1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed]
2 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]
3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: P35583
Notes: experiment type:PBM, family:Forkhead
Length: 459
Pfam Domains: 17-158 Forkhead N-terminal region
159-254 Fork head domain
374-448 HNF3 C-terminal domain
Sequence:
(in bold interface residues)
1 MLGAVKMEGHEPSDWSSYYAEPEGYSSVSNMNAGLGMNGMNTYMSMSAAAMGGGSGNMSA 60
61 GSMNMSSYVGAGMSPSLAGMSPGAGAMAGMSGSAGAAGVAGMGPHLSPSLSPLGGQAAGA 120
121 MGGLAPYANMNSMSPMYGQAGLSRARDPKTYRRSYTHAKPPYSYISLITMAIQQSPNKML 180
181 TLSEIYQWIMDLFPFYRQNQQRWQNSIRHSLSFNDCFLKVPRSPDKPGKGSFWTLHPDSG 240
241 NMFENGCYLRRQKRFKCEKQLALKEAAGAASSGGKKTAPGSQASQAQLGEAAGSASETPA 300
301 GTESPHSSASPCQEHKRGGLSELKGAPASALSPPEPAPSPGQQQQAAAHLLGPPHHPGLP 360
361 PEAHLKPEHHYAFNHPFSINNLMSSEQQHHHSHHHHQPHKMDLKAYEQVMHYPGGYGSPM 420
421 PGSLAMGPVTNKAGLDASPLAADTSYYQGVYSRPIMNSS
Interface Residues: 149, 151, 153, 154, 156, 202, 204, 205, 206, 208, 209, 210, 212, 213, 222, 229, 254
3D-footprint Homologues: 7yz7_A, 7yzb_A, 7vox_H, 2hdc_A, 6nce_A, 2uzk_A, 7vou_C, 2a07_J, 7yze_A, 7cby_C, 3co6_C, 6ako_C, 2c6y_A, 7yzg_A, 7tdw_A, 3g73_A, 6el8_A, 7tdx_A, 3l2c_A, 3qrf_G
Binding Motifs: MA0047.2 TRTTTACwywgg
PB0015.1 wawawGTAAAyAAwvab
PB0119.1 rrwaaTAACAaasgs
M0729_1.02 GTAAAyAa
FOXA2_MOUSE.H10MO.B|M01095 tTrTTTACwywg
Binding Sites: MA0047.2.1
MA0047.2.10
MA0047.2.11
MA0047.2.12
MA0047.2.13
MA0047.2.14
MA0047.2.15
MA0047.2.16
MA0047.2.17
MA0047.2.18
MA0047.2.19
MA0047.2.2
MA0047.2.20
MA0047.2.3
MA0047.2.4
MA0047.2.5
MA0047.2.6
MA0047.2.7
MA0047.2.8
MA0047.2.9
Publications: Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed]

Tuteja G, White P, Schug J, Kaestner K.H. Extracting transcription factor targets from ChIP-Seq data. Nucleic acids research 37:e113 (2009). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.