Transcription Factor
| Accessions: | CREB5 (HT-SELEX2 May2017) |
| Names: | CREB5, ENSG00000146592 |
| Organisms: | Homo sapiens |
| Libraries: | HT-SELEX2 May2017 1 1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Notes: | TF family: bZIP experiment: HT-SELEX Hamming distance: 1 cycle: 3, TF family: bZIP experiment: HT-SELEX Hamming distance: 1 cycle: 4, TF family: bZIP experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 3, TF family: bZIP experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 4 |
| Length: | 458 |
| Pfam Domains: | 373-426 Basic region leucine zipper 376-433 bZIP transcription factor |
| Sequence: (in bold interface residues) | 1 IYEESKMNLEQERPSVCSAPGCSQRFPTEDHLMIHRHKHEMTLKFPSIKTDNMLSDQTPT 60 61 PTRFLKNCEEVGLFSELDCSLEHEFRKAQEEESSKRNISMHNAVGGAMTGPGTHQLSSAR 120 121 LPNHDTNVVIQQAMPSPQSSSVITQAPSTNRQIGPVPGSLSSLLHLHNRQRQPMPASMPG 180 181 TLPNPTMPGSSAVLMPMERQMSVNSSIMGIEGPNLSNPCASPQVQPMHSEAKMRLKAALT 240 241 HHPAAMSNGNMNTMGHMMEMMGSRQDQTPHHHMHSHPHQHQTLPPHHPYPHQHQHPAHHP 300 301 HPQPHHQQNHPHHHSHSHLHAHPAHHQTSPHPPLHTGNQAQVSPATQQMQPTQTIQPPQP 360 361 TGGRRRRVVDEDPDERRRKFLERNRAAATRCRQKRKVWVMSLEKKAEELTQTNMQLQNEV 420 421 SMLKNEVAQLKQLLLTHKDCPITAMQKESQGYLSPESS |
| Interface Residues: | 28, 30, 31, 33, 34, 36, 37, 38, 378, 380, 384, 385, 387, 388, 391, 392 |
| 3D-footprint Homologues: | 7y3m_I, 5kl3_A, 6blw_A, 2wbs_A, 2jpa_A, 7x5e_E, 2wt7_B, 2wt7_A, 5vpe_D, 1dh3_C, 5t01_B, 1nwq_C, 6mg1_B, 5vpe_C, 2dgc_A |
| Binding Motifs: | CREB5_2 srTgAYGTmAys CREB5_4 grTKACGTMAyc CREB5_methyl_1 grTGAyGTMAys CREB5_methyl_3 gRTGAyGTCATy |
| Related annotations: | PaperBLAST |
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