Transcription Factor
| Accessions: | Q92766 (JASPAR 2024) |
| Names: | Finger protein in nuclear bodies, Raf-responsive zinc finger protein LZ321, Ras-responsive element-binding protein 1, RREB-1, RREB1_HUMAN, Zep-1, Zinc finger motif enhancer-binding protein 1 |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q92766 |
| Length: | 1687 |
| Pfam Domains: | 66-89 C2H2-type zinc finger 97-119 C2H2-type zinc finger 97-119 Zinc finger, C2H2 type 111-136 Zinc-finger double domain 125-147 C2H2-type zinc finger 125-147 Zinc finger, C2H2 type 208-230 C2H2-type zinc finger 643-665 C2H2-type zinc finger 658-678 Zinc-finger double domain 671-693 C2H2-type zinc finger 671-693 Zinc finger, C2H2 type 686-709 Zinc-finger double domain 699-722 C2H2-type zinc finger 767-800 Zinc-finger double domain 1247-1268 Zinc finger, C2H2 type 1248-1268 C2H2-type zinc finger 1395-1415 Zinc finger, C2H2 type 1513-1534 Zinc-finger of C2H2 type 1514-1534 C2H2-type zinc finger 1526-1550 Zinc-finger double domain 1540-1562 Zinc finger, C2H2 type 1540-1562 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 MTSSSPAGLEGSDLSSINTMMSAVMSVGKVTENGGSPQGIKSPSKPPGPNRIGRRNQETK 60 61 EEKSSYNCPLCEKICTTQHQLTMHIRQHNTDTGGADHSCSICGKSLSSASSLDRHMLVHS 120 121 GERPYKCTVCGQSFTTNGNMHRHMKIHEKDPNSATATAPPSPLKRRRLSSKRKLSHDAES 180 181 EREDPAPAKKMVEDGQSGDLEKKADEVFHCPVCFKEFVCKYGLETHMETHSDNPLRCDIC 240 241 CVTFRTHRGLLRHNALVHKQLPRDAMGRPFIQNNPSIPAGFHDLGFTDFSCRKFPRISQA 300 301 WCETNLRRCISEQHRFVCDTCDKAFPMLCSLALHKQTHVAADQGQEKPQATPLPGDALDQ 360 361 KGFLALLGLQHTKDVRPAPAEEPLPDDNQAIQLQTLKCQLPQDPGCTNLLSLSPFEAASL 420 421 GGSLTVLPATKDSIKHLSLQPFQKGFIIQPDSSIVVKPISGESAIELADIQQILKMAASA 480 481 PPQISLPPFSKAPAAPLQAIFKHMPPLKPKPLVTPRTVVATSTPPPLINAQQASPGCISP 540 541 SLPPPPLKLLKGSVEAASNAHLLQSKSGTQPHAATRLSLQQPRAELPGQPEMKTQLEQDS 600 601 IIEALLPLSMEAKIKQEITEGELKAFMTAPGGKKTPAMRKVLYPCRFCNQVFAFSGVLRA 660 661 HVRSHLGISPYQCNICDYIAADKAALIRHLRTHSGERPYICKICHYPFTVKANCERHLRK 720 721 KHLKATRKDIEKNIEYVSSSAAELVDAFCAPDTVCRLCGEDLKHYRALRIHMRTHCGRGL 780 781 GGGHKGRKPFECKECSAAFAAKRNCIHHILKQHLHVPEQDIESYVLAADGLGPAEAPAAE 840 841 ASGRGEDSGCAALGDCKPLTAFLEPQNGFLHRGPTQPPPPHVSIKLEPASSFAVDFNEPL 900 901 DFSQKGLALVQVKQENISFLSPSSLVPYDCSMEPIDLSIPKNFRKGDKDLATPSEAKKPE 960 961 EEAGSSEQPSPCPAPGPSLPVTLGPSGILESPMAPAPAATPEPPAQPLQGPVQLAVPIYS 1020 1021 SALVSSPPLVGSSALLSGTALLRPLRPKPPLLLPKPPVTEELPPLASIAQIISSVSSAPT 1080 1081 LLKTKVADPGPASTGSNTTASDSLGGSVPKAATTATPAATTSPKESSEPPAPASSPEAAS 1140 1141 PTEQGPAGTSKKRGRKRGMRSRPRANSGGVDLDSSGEFASIEKMLATTDTNKFSPFLQTA 1200 1201 EDNTQDEVAGAPADHHGPSDEEQGSPPEDKLLRAKRNSYTNCLQKITCPHCPRVFPWASS 1260 1261 LQRHMLTHTDSQSDAETAAAAGEVLDLTSRDREQPSEGATELRQVAGDAPVEQATAETAS 1320 1321 PVHREEHGRGESHEPEEEHGTEESTGDADGAEEDASSNQSLDLDFATKLMDFKLAEGDGE 1380 1381 AGAGGAASQEQKLACDTCGKSFKFLGTLSRHRKAHGRQEPKDEKGDGASTAEEGPQPAPE 1440 1441 QEEKPPETPAEVVESAPGAGEAPAEKLAEETEGPSDGESAAEKRSSEKSDDDKKPKTDSP 1500 1501 KSVASKADKRKKVCSVCNKRFWSLQDLTRHMRSHTGERPYKCQTCERTFTLKHSLVRHQR 1560 1561 IHQKARHAKHHGKDSDKEERGEEDSENESTHSGNNAVSENEAELAPNASNHMAVTRSRKE 1620 1621 GLASATKDCSHREEKVTAGWPSEPGQGDLNPESPAALGQDLLEPRSKRPAHPILATADGA 1680 1681 SQLVGME |
| Interface Residues: | 55, 76, 77, 78, 79, 80, 83, 86, 87, 107, 108, 109, 110, 111, 113, 114, 115, 135, 136, 137, 138, 139, 140, 142, 143, 146, 164, 167, 228, 231, 232, 246, 248, 249, 252, 619, 620, 622, 625, 629, 653, 654, 656, 657, 660, 681, 682, 683, 684, 685, 688, 709, 710, 711, 712, 713, 714, 716, 720, 740, 741, 742, 743, 764, 765, 766, 767, 770, 785, 799, 801, 803, 804, 807, 1522, 1523, 1525, 1526, 1528, 1529, 1531, 1532, 1535, 1551, 1553, 1554, 1556, 1557 |
| 3D-footprint Homologues: | 2i13_A, 6ml4_A, 7n5w_A, 2lt7_A, 4x9j_A, 1mey_C, 1g2f_F, 7eyi_G, 8h9h_G, 5v3j_F, 1ubd_C, 8cuc_F, 7y3l_A, 2kmk_A, 8gn3_A, 2drp_D, 6wmi_A, 4m9v_C, 7y3m_I, 5yj3_D, 1yuj_A, 8ssq_A, 7w1m_H, 8ssu_A, 5kkq_D, 1tf3_A, 1tf6_A, 5und_A, 2gli_A, 6u9q_A, 5ei9_F, 5kl3_A, 7ysf_A, 5k5i_A, 2wbs_A, 5yel_A, 7txc_E, 6jnm_A, 3uk3_C, 1llm_D, 5k5l_F, 6blw_A, 1f2i_J, 6e94_A, 6a57_A, 2jpa_A |
| Binding Motifs: | MA0073.1 MCMCmAMmCAmCMmCmmmsm MA0073.2 MCMCmAMmCAmCMmCmmms |
| Binding Sites: | MA0073.1.1 MA0073.1.10 MA0073.1.11 MA0073.1.2 MA0073.1.3 MA0073.1.4 MA0073.1.5 MA0073.1.6 MA0073.1.7 MA0073.1.8 MA0073.1.9 MA0073.2.1 MA0073.2.10 MA0073.2.11 MA0073.2.2 MA0073.2.3 MA0073.2.4 MA0073.2.5 MA0073.2.6 MA0073.2.7 MA0073.2.8 MA0073.2.9 |
| Publications: | Thiagalingam A., de Bustros A., Borges M., Jasti R., Compton D., Diamond L., Mabry M., Ball D. W., Baylin S. B., Nelkin B. D. RREB-1, a novel zinc finger protein, is involved in the differentiation response to Ras in human medullary thyroid carcinomas. Mol. Cell. Biol. 16:5335-5345 (1996). [Pubmed] |
| Related annotations: | PaperBLAST |
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