Transcription Factor

Accessions: T019537_1.02 (CISBP 1.02), A9RZ73 (JASPAR 2018)
Names: fgenesh1_pg.scaffold_37000071, T019537_1.02;, A9RZ73_PHYPA
Organisms: Physcomitrella patens, moss
Libraries: CISBP 1.02 1, JASPAR 2018 2
1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed]
2 [Pubmed]
Notes: experiment type:PBM, family:bHLH
Length: 845
Pfam Domains: 329-378 Helix-loop-helix DNA-binding domain
Sequence:
(in bold interface residues)
1 MAFVATAGQKQLVPERAIRSSSSLGYSSFGELAPGDSVTQQQREFQVVHRYTMAQQHAER 60
61 AQSRHFAHSEDTKPSTHDFLSLYDKGSQQAENVSSAGLSSSLTTHDFLQPLERNGARPTS 120
121 RDAPVLREKHSSGENGQSRHSTPGPGEQAHPTSSPNYAAIKVPYTVPPNSMLRMVGEAEA 180
181 VRQGRNYPIATLSSREDHSGSETFKGVEIAVGPEAANAQENLAHWPGVRFQFGMPPDLTF 240
241 TAGNPAAKSVVENGHQLLPTMTKHWAQAAQGMIESPKRPARPPSDEDEDDDEDSSERPKV 300
301 NRKEPMLRKGDGAQRMDSKNADLRGVTPRSKHSATEQRRRSKINDRFQMLRDLVPHSDQK 360
361 RDKASFLLEVIEYIQVLQDKVRKYETVEQGRHQERLKSMVWDLCKRGAAGSGDETSQINA 420
421 LVFAKDLNSGVRSVDIKPGTEVPADRVPRSSEEAAPISEAHSTGGLNAQQASSRPACSIH 480
481 SCVSSLGGEKESATAVTAVGVPLQQAIPSPHAFPIVPSKGQREQDSNRGTPASNSNAPRK 540
541 EKTSDMDLVSSRENGYAHDTTPDHQFEVRPRISSGQADQNSDHQPKDHQMSATTIVGRMD 600
601 GVQAGLLSSAPRQPQGGPQHKEDANKHTRHPQTNQNDHMATRDGFAVFPNIPQPFPRIQG 660
661 GVINVSSVYSQGLLDTLTRALQSSGVDLSRANISVQIDLGKNATVAPGDTSAKVATTPES 720
721 SAQSHQSQGRTRPAPSVPESEPARKRPKLLSSAYTKHHCLLRSGCGKIEKDRFGFRLCYD 780
781 QHDAGFWHNECRSFGLSFAKISLSGLEMAIWRTALLRFVISFEPTSAGKEGVHAVVACSL 840
841 ITIFH
Interface Residues: 329, 331, 332, 333, 335, 336, 339, 340, 361
3D-footprint Homologues: 1mdy_C, 1an4_A, 5v0l_A, 1nkp_E, 5gnj_I, 1hlo_B, 4ati_B, 5i50_B, 4h10_A, 1am9_A, 5nj8_D, 1nkp_A, 4h10_B
Binding Motifs: M0251_1.02 rkCACGTGmy
MA1011.1 rkCACGTGmy
Publications: Fernández-Calvo P, Chini A, Fernández-Barbero G, Chico J.M, Gimenez-Ibanez S, Geerinck J, Eeckhout D, Schweizer F, Godoy M, Franco-Zorrilla J.M, Pauwels L, Witters E, Puga M.I, Paz-Ares J, Goossens A, Reymond P, De Jaeger G, Solano R. The Arabidopsis bHLH transcription factors MYC3 and MYC4 are targets of JAZ repressors and act additively with MYC2 in the activation of jasmonate responses. The Plant cell 23:701-15 (2011). [Pubmed]

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