Transcription Factor
| Accessions: | SRF_HUMAN (HOCOMOCO 10), P11831 (JASPAR 2024) |
| Names: | Serum response factor, SRF_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 508 |
| Pfam Domains: | 149-199 SRF-type transcription factor (DNA-binding and dimerisation domain) |
| Sequence: (in bold interface residues) | 1 MLPTQAGAAAALGRGSALGGSLNRTPTGRPGGGGGTRGANGGRVPGNGAGLGPGRLEREA 60 61 AAAAATTPAPTAGALYSGSEGDSESGEEEELGAERRGLKRSLSEMEIGMVVGGPEASAAA 120 121 TGGYGPVSGAVSGAKPGKKTRGRVKIKMEFIDNKLRRYTTFSKRKTGIMKKAYELSTLTG 180 181 TQVLLLVASETGHVYTFATRKLQPMITSETGKALIQTCLNSPDSPPRSDPTTDQRMSATG 240 241 FEETDLTYQVSESDSSGETKDTLKPAFTVTNLPGTTSTIQTAPSTSTTMQVSSGPSFPIT 300 301 NYLAPVSASVSPSAVSSANGTVLKSTGSGPVSSGGLMQLPTSFTLMPGGAVAQQVPVQAI 360 361 QVHQAPQQASPSRDSSTDLTQTSSSGTVTLPATIMTSSVPTTVGGHMMYPSPHAVMYAPT 420 421 SGLGDGSLTVLNAFSQAPSTMQVSHSQVQEPGGVPQVFLTASSGTVQIPVSAVQLHQMAV 480 481 IGQQAGSSSNLTELQVVNLDTAHSTKSE |
| Interface Residues: | 140, 143, 144, 155, 158, 159, 163 |
| 3D-footprint Homologues: | 1hbx_A, 1n6j_A, 1c7u_A, 7x1n_C, 1mnm_A |
| Binding Motifs: | MA0083.3 TgmCCATATAWGGkcA MA0083.2 yatkyCCAwAWAwGGmaa SRF_HUMAN.H10MO.A|M01535 atTbkCCTtmYwtGGccw MA0083.1 GCCCWTATAwGG |
| Binding Sites: | MA0083.1.1 MA0083.1.10 MA0083.1.11 MA0083.1.12 MA0083.1.13 MA0083.1.14 MA0083.1.15 MA0083.1.16 MA0083.1.17 MA0083.1.18 MA0083.1.19 MA0083.1.2 MA0083.1.20 MA0083.1.3 MA0083.1.4 MA0083.1.5 / MA0083.1.7 MA0083.1.6 MA0083.1.8 MA0083.1.9 MA0083.2.1 MA0083.2.10 / MA0083.2.18 MA0083.2.11 MA0083.2.12 MA0083.2.13 MA0083.2.14 MA0083.2.15 MA0083.2.16 MA0083.2.17 / MA0083.2.19 MA0083.2.2 MA0083.2.20 MA0083.2.3 MA0083.2.4 MA0083.2.5 MA0083.2.6 MA0083.2.7 MA0083.2.8 MA0083.2.9 |
| Publications: | Pollock R., Treisman R. A sensitive method for the determination of protein-DNA binding specificities. Nucleic Acids Res. 18:6197-6204 (1990). [Pubmed] |
| Related annotations: | PaperBLAST |
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