Transcription Factor

Accessions: Q01167 (JASPAR 2024), ForkheadK2 (EEADannot 2023-12-22)
Names: Cellular transcription factor ILF-1, Forkhead box protein K2, FOXK1, FOXK2_HUMAN, G/T-mismatch specific binding protein, Interleukin enhancer-binding factor 1, nGTBP, Forkhead K2, NP_004505.2
Organisms: Homo sapiens
Libraries: JASPAR 2024 1, EEADannot 2023-12-22 2
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
2 Contreras-Moreira B, Sebastian A. FootprintDB: Analysis of Plant Cis-Regulatory Elements, Transcription Factors, and Binding Interfaces. Methods Mol Biol 1482:259-77 (2016) [Pubmed]
Notes: family:Forkhead
Length: 660
Pfam Domains: 54-130 FHA domain
258-352 Fork head domain
Sequence:
(in bold interface residues)
1 MAAAAAALSGAGTPPAGGGAGGGGAGGGGSPPGGWAVARLEGREFEYLMKKRSVTIGRNS 60
61 SQGSVDVSMGHSSFISRRHLEIFTPPGGGGHGGAAPELPPAQPRPDAGGDFYLRCLGKNG 120
121 VFVDGVFQRRGAPPLQLPRVCTFRFPSTNIKITFTALSSEKREKQEASESPVKAVQPHIS 180
181 PLTINIPDTMAHLISPLPSPTGTISAANSCPSSPRGAGSSGYKVGRVMPSDLNLMADNSQ 240
241 PENEKEASGGDSPKDDSKPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADK 300
301 GWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRIDPASESKLIEQAFRKRRPRGVPCFRT 360
361 PLGPLSSRSAPASPNHAGVLSAHSSGAQTPESLSREGSPAPLEPEPGAAQPKLAVIQEAR 420
421 FAQSAPGSPLSSQPVLITVQRQLPQAIKPVTYTVATPVTTSTSQPPVVQTVHVVHQIPAV 480
481 SVTSVAGLAPANTYTVSGQAVVTPAAVLAPPKAEAQENGDHREVKVKVEPIPAIGHATLG 540
541 TASRIIQTAQTTPVQTVTIVQQAPLGQHQLPIKTVTQNGTHVASVPTAVHGQVNNAAASP 600
601 LHMLATHASASASLPTKRHNGDQPEQPELKRIKTEDGEGIVIALSVDTPPAAVREKGVQN 660
Interface Residues: 298, 301, 303, 304, 305, 307, 308, 309, 311, 312, 321, 328, 353
3D-footprint Homologues: 3l2c_A, 7vox_H, 2hdc_A, 7yzb_A, 6nce_A, 2uzk_A, 7vou_C, 2a07_J, 7yze_A, 7cby_C, 3co6_C, 6ako_C, 2c6y_A, 7yzg_A, 7tdw_A, 3g73_A, 7yz7_A, 6el8_A, 7tdx_A, 3qrf_G
Binding Motifs: MA1103.1 awgTAAACAar
MA1103.2 awGTAAACAar
EEAD0010 sCwTGTTTAC
MA1103.3 GTAAACA
Binding Sites: MA1103.3.12 / MA1103.3.16 / MA1103.3.4
MA1103.3.1
MA1103.1.1 / MA1103.2.2 / MA1103.2.4
MA1103.1.10 / MA1103.1.5 / MA1103.2.11 / MA1103.2.13 / MA1103.2.18
MA1103.1.11
MA1103.1.12
MA1103.1.13
MA1103.1.14
MA1103.1.15
MA1103.1.16
MA1103.1.17
MA1103.1.18
MA1103.1.19
MA1103.1.2 / MA1103.2.10 / MA1103.2.8
MA1103.1.20
MA1103.1.3 / MA1103.2.11 / MA1103.2.9
MA1103.1.4 / MA1103.2.10
MA1103.1.6 / MA1103.2.12 / MA1103.2.14
MA1103.1.7 / MA1103.2.13 / MA1103.2.16
MA1103.1.8 / MA1103.2.16 / MA1103.2.19
MA1103.1.9 / MA1103.2.17 / MA1103.2.20
MA1103.3.6
MA1103.2.3 / MA1103.2.5
MA1103.2.6 / MA1103.2.8
MA1103.2.1
MA1103.2.12
MA1103.2.15
MA1103.2.14 / MA1103.2.17
MA1103.2.18
MA1103.2.2
MA1103.2.1 / MA1103.2.3
MA1103.2.4 / MA1103.2.6
MA1103.2.5 / MA1103.2.7
MA1103.2.9
MA1103.2.15
MA1103.2.19
MA1103.2.20
MA1103.2.7
MA1103.3.11 / MA1103.3.13 / MA1103.3.14 / MA1103.3.18 / MA1103.3.9
MA1103.3.2 / MA1103.3.8
MA1103.3.19
MA1103.3.20
MA1103.3.7
MA1103.3.10
MA1103.3.3 / MA1103.3.5
MA1103.3.15
MA1103.3.17
Publications: Chen X, Ji Z, Webber A, Sharrocks AD. Genome-wide binding studies reveal DNA binding specificity mechanisms and functional interplay amongst Forkhead transcription factors. Nucleic Acids Res 44:1566-78 (2016). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.