Transcription Factor

Accessions: ATOH7 (HT-SELEX2 May2017)
Names: ATOH7, ENSG00000179774
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]
Notes: TF family: bHLH experiment: HT-SELEX Hamming distance: 1 cycle: 3, TF family: bHLH experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 3
Length: 103
Pfam Domains: 27-78 Helix-loop-helix DNA-binding domain
Sequence:
(in bold interface residues)
1 VAPPCAGGTECAGTCAGAGRLESAARRRLAANARERRRMQGLNTAFDRLRRVVPQWGQDK 60
61 KLSKYETLQMALSYIMALTRILAEAERFGSERDWVGLHCEHFG
Interface Residues: 28, 30, 31, 32, 34, 35, 36, 37, 38, 39, 49, 64
3D-footprint Homologues: 7z5k_B, 2ypa_A, 1an4_A, 6od3_F, 7f2f_B, 5i50_B, 7rcu_E, 5eyo_A, 2ypa_B, 2ql2_A, 2ql2_D, 5nj8_C, 5gnj_I, 4h10_A, 8osl_P, 7ssa_L, 8e24_A, 4x0q_B
Binding Motifs: ATOH7_2 AmCATATGky
ATOH7_methyl_1 AmCATATGky
Related annotations: PaperBLAST

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