Transcription Factor

Accessions: PBX1_HUMAN (HOCOMOCO 10), PBX1_MOUSE (HOCOMOCO 10), P40424 (JASPAR 2024), P41778 (JASPAR 2024)
Names: Homeobox protein PBX1, Homeobox protein PRL, PBX1_HUMAN, Pre-B-cell leukemia transcription factor 1, PBX1_MOUSE
Organisms: Homo sapiens, Mus musculus
Libraries: HOCOMOCO 10 1, JASPAR 2024 2
1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Length: 430
Pfam Domains: 38-232 PBC domain
234-293 Homeobox domain
252-290 Homeobox KN domain
Sequence:
(in bold interface residues)
1 MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDE 60
61 AQARKHALNCHRMKPALFNVLCEIKEKTVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGP 120
121 EKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVM 180
181 NLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNF 240
241 NKQATEILNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQE 300
301 EANIYAAKTAVTATNVSAHGSQANSPSTPNSAGSSSSFNMSNSGDLFMSVQSLNGDSYQG 360
361 AQVGANVQSQVDTLRHVISQTGGYSDGLAASQMYSPQGISANGGWQDATTPSSVTSPTEG 420
421 PGSVHSDTSN
Interface Residues: 91, 108, 109, 115, 179, 195, 196, 198, 199, 207, 213, 216, 217, 220, 234, 235, 236, 237, 238, 278, 279, 281, 282, 285, 286, 289, 290, 293
3D-footprint Homologues: 2fr4_L, 2p7c_B, 1au7_A, 5zfz_A, 6fqp_B, 3cmy_A, 1puf_A, 6a8r_A, 3d1n_M, 1fjl_B, 2h1k_B, 1zq3_P, 1jgg_B, 3lnq_A, 2lkx_A, 6m3d_C, 2ld5_A, 7psx_B, 4j19_B, 3a01_E, 2h8r_B, 1b72_A, 5zjt_E, 5hod_A, 1puf_B, 4cyc_A, 2r5y_A, 3rkq_B, 3l1p_A, 5jlw_D, 7q3o_C, 1le8_A, 1mnm_C, 5flv_I, 2d5v_B, 1k61_B, 4qtr_D, 2hdd_A, 6fqq_E, 1du0_A, 4xrm_B, 1le8_B, 6es3_K, 4xrs_G, 2hos_A
Binding Motifs: PBX1_HUMAN.H10MO.B|M01427 / PBX1_MOUSE.H10MO.B|M01283 wawwTGATTGATgdg
MA0070.1 hcATCAATCAww
PH0134.1 yyaymCATCAAwmwwmm
MA0070.2 ATCAATCAw
Binding Sites: MA0070.1.1
MA0070.1.10
MA0070.1.11
MA0070.1.12
MA0070.1.13
MA0070.1.14
MA0070.1.15
MA0070.1.16
MA0070.1.17
MA0070.1.18
MA0070.1.2
MA0070.1.3
MA0070.1.4
MA0070.1.5
MA0070.1.6
MA0070.1.7
MA0070.1.8
MA0070.1.9
MA0070.2.1
MA0070.2.10
MA0070.2.11
MA0070.2.12
MA0070.2.13
MA0070.2.14
MA0070.2.15
MA0070.2.16
MA0070.2.17
MA0070.2.18
MA0070.2.2 / MA0070.2.7
MA0070.2.3
MA0070.2.4
MA0070.2.5
MA0070.2.6
MA0070.2.8
MA0070.2.9
Publications: Lu Q., Wright D. D., Kamps M. P. Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation. Mol. Cell. Biol. 14:3938-3948 (1994). [Pubmed]

Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed]
Related annotations: PaperBLAST

Disclaimer and license

These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.