Transcription Factor
Accessions: | PBX1_HUMAN (HOCOMOCO 10), PBX1_MOUSE (HOCOMOCO 10), P40424 (JASPAR 2024), P41778 (JASPAR 2024) |
Names: | Homeobox protein PBX1, Homeobox protein PRL, PBX1_HUMAN, Pre-B-cell leukemia transcription factor 1, PBX1_MOUSE |
Organisms: | Homo sapiens, Mus musculus |
Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
Length: | 430 |
Pfam Domains: | 38-232 PBC domain 234-293 Homeobox domain 252-290 Homeobox KN domain |
Sequence: (in bold interface residues) | 1 MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDE 60 61 AQARKHALNCHRMKPALFNVLCEIKEKTVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGP 120 121 EKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVM 180 181 NLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNF 240 241 NKQATEILNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQE 300 301 EANIYAAKTAVTATNVSAHGSQANSPSTPNSAGSSSSFNMSNSGDLFMSVQSLNGDSYQG 360 361 AQVGANVQSQVDTLRHVISQTGGYSDGLAASQMYSPQGISANGGWQDATTPSSVTSPTEG 420 421 PGSVHSDTSN |
Interface Residues: | 91, 108, 109, 115, 179, 195, 196, 198, 199, 207, 213, 216, 217, 220, 234, 235, 236, 237, 238, 278, 279, 281, 282, 285, 286, 289, 290, 293 |
3D-footprint Homologues: | 2fr4_L, 2p7c_B, 1au7_A, 5zfz_A, 6fqp_B, 3cmy_A, 1puf_A, 6a8r_A, 3d1n_M, 1fjl_B, 2h1k_B, 1zq3_P, 1jgg_B, 3lnq_A, 2lkx_A, 6m3d_C, 2ld5_A, 7psx_B, 4j19_B, 3a01_E, 2h8r_B, 1b72_A, 5zjt_E, 5hod_A, 1puf_B, 4cyc_A, 2r5y_A, 3rkq_B, 3l1p_A, 5jlw_D, 7q3o_C, 1le8_A, 1mnm_C, 5flv_I, 2d5v_B, 1k61_B, 4qtr_D, 2hdd_A, 6fqq_E, 1du0_A, 4xrm_B, 1le8_B, 6es3_K, 4xrs_G, 2hos_A |
Binding Motifs: | PBX1_HUMAN.H10MO.B|M01427 / PBX1_MOUSE.H10MO.B|M01283 wawwTGATTGATgdg MA0070.1 hcATCAATCAww PH0134.1 yyaymCATCAAwmwwmm MA0070.2 ATCAATCAw |
Binding Sites: | MA0070.1.1 MA0070.1.10 MA0070.1.11 MA0070.1.12 MA0070.1.13 MA0070.1.14 MA0070.1.15 MA0070.1.16 MA0070.1.17 MA0070.1.18 MA0070.1.2 MA0070.1.3 MA0070.1.4 MA0070.1.5 MA0070.1.6 MA0070.1.7 MA0070.1.8 MA0070.1.9 MA0070.2.1 MA0070.2.10 MA0070.2.11 MA0070.2.12 MA0070.2.13 MA0070.2.14 MA0070.2.15 MA0070.2.16 MA0070.2.17 MA0070.2.18 MA0070.2.2 / MA0070.2.7 MA0070.2.3 MA0070.2.4 MA0070.2.5 MA0070.2.6 MA0070.2.8 MA0070.2.9 |
Publications: | Lu Q., Wright D. D., Kamps M. P. Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation. Mol. Cell. Biol. 14:3938-3948 (1994). [Pubmed] Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.