Transcription Factor
| Accessions: | O35745 (JASPAR 2024) |
| Names: | O35745_MOUSE |
| Organisms: | Mus musculus |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | O35745 |
| Length: | 667 |
| Pfam Domains: | 4-26 Zinc finger, C2H2 type 20-45 Zinc-finger double domain 32-56 C2H2-type zinc finger 32-56 Zinc finger, C2H2 type 49-72 Zinc-finger double domain 62-84 C2H2-type zinc finger 62-84 Zinc finger, C2H2 type 76-102 Zinc-finger double domain 135-167 Zinc-finger double domain 156-178 C2H2-type zinc finger 156-178 Zinc finger, C2H2 type 184-207 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 MAPFRCQKCGKSFVTLEKFTIHNYSHSRERPFKCSKAECGKAFVSKYKLMRHMATHSPQK 60 61 IHQCTHCEKTFNRKDHLKNHLQTHDPNKISYACDDCGKKYHTMLGYKRHLALHSASNGDL 120 121 TCGVCTLELGSTEVLLDHLKSHAEEKANQAPREKKYQCDHCDRCFYTRKDVRRHLVVHTG 180 181 CKDFLCQFCAQRFGRKDHLTRHTKKTHSQELMQENMQAGDYQSNFQLIAPSTSFQIKVDP 240 241 MPPFQLGAAPENGLDGGLPPEVHGLVLAAPEEAPQPMPPLEPLEPLEPLEPLEPMQSLEP 300 301 LQPLEPMQPLEPMQPLEPMQPLEPLEPLEPMQPLEPMQPLEPMQPMLPMQPMQPMQPMQP 360 361 MLPMQPMLPMQPMQPMQPMLPMPEPSFTLHPGVVPTSPPPIILQEHKYNPVPTSYAPFVG 420 421 MPVKADGKAFCNVGFFEEFPLQEPQAPLKFNPCFEMPMEGFGKVTLSKELLVDAVNIAIP 480 481 ASLEISSLLGFWQLPPPTPQNGFVNSTIPVGPGEPLPHRITCLAQQQPPPLPPPPPLPLP 540 541 QPLPVPQPLPQPQMQPQFQLQIQPQMQLPQLLPQLQPQQQPDPEPEPEPEPEPEPEPEPE 600 601 PEPEPEPEPEPEPEEEQEEAEEEAEEGAEEGAEPEAQAEEEEEEEEAEEPQPEEAQIAGL 660 661 VYKKWTV |
| Interface Residues: | 4, 14, 15, 16, 17, 18, 20, 21, 22, 23, 24, 27, 44, 45, 46, 47, 48, 49, 51, 52, 72, 73, 74, 75, 76, 78, 79, 101, 102, 103, 104, 105, 106, 107, 108, 109, 112, 114, 130, 131, 133, 134, 137, 143, 146, 149, 152, 167, 168, 169, 170, 171, 172, 173, 174, 177, 194, 195, 196, 197, 198, 201, 237 |
| 3D-footprint Homologues: | 2kmk_A, 6jnm_A, 8cuc_F, 7y3l_A, 6blw_A, 5kkq_D, 1ubd_C, 6u9q_A, 5ei9_F, 1mey_C, 6wmi_A, 8ssq_A, 7w1m_H, 5und_A, 2gli_A, 7eyi_G, 8ssu_A, 4m9v_C, 2i13_A, 6a57_A, 2jpa_A, 7n5w_A, 3uk3_C, 1tf3_A, 2wbs_A, 7txc_E, 5kl3_A, 1f2i_J, 5yj3_D, 5k5i_A, 1g2f_F, 1tf6_A, 5v3j_F, 4x9j_A, 8h9h_G, 7ysf_A, 5yel_A, 1llm_D, 6ml4_A, 2lt7_A, 6e94_A, 8gn3_A, 2drp_D, 5k5l_F, 7y3m_I |
| Binding Motifs: | PB0052.1 kyggGGGssCCCckrs PB0156.1 rctgGGGGGTACccytw MA1615.1 ssctGGGGCCAss MA1615.2 tGGGGCCA |
| Binding Sites: | MA1615.1.1 MA1615.1.10 MA1615.1.11 MA1615.1.12 MA1615.1.13 MA1615.1.14 MA1615.1.15 MA1615.1.16 MA1615.1.17 MA1615.1.18 MA1615.1.19 MA1615.1.2 MA1615.1.20 MA1615.1.3 MA1615.1.4 MA1615.1.5 MA1615.1.6 MA1615.1.7 / MA1615.1.8 MA1615.1.9 |
| Publications: | Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed] Varrault A, Dantec C, Le Digarcher A, Chotard L, Bilanges B, Parrinello H, Dubois E, Rialle S, Severac D, Bouschet T, Journot L. Identification of Plagl1/Zac1 binding sites and target genes establishes its role in the regulation of extracellular matrix genes and the imprinted gene network. Nucleic Acids Res 45:10466-10480 (2017). [Pubmed] |
| Related annotations: | PaperBLAST |
Disclaimer and license
These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.