Transcription Factor

Accessions: T078264_1.02 (CISBP 1.02), SPI1_MOUSE (HOCOMOCO 10), P17433 (JASPAR 2024)
Names: Sfpi1, T078264_1.02;, 31 kDa-transforming protein, SFFV proviral integration 1 protein, SPI1_MOUSE, Transcription factor PU.1
Organisms: Mus musculus
Libraries: CISBP 1.02 1, HOCOMOCO 10 2, JASPAR 2024 3
1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed]
2 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]
3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: experiment type:PBM, family:Ets
Length: 272
Pfam Domains: 171-255 Ets-domain
Sequence:
(in bold interface residues)
1 MLQACKMEGFSLTAPPSDDLVTYDSELYQRPMHDYYSFVGSDGESHSDHYWDFSAHHVHN 60
61 NEFENFPENHFTELQSVQPPQLQQLYRHMELEQMHVLDTPMVPPHTGLSHQVSYMPRMCF 120
121 PYQTLSPAHQQSSDEEEGERQSPPLEVSDGEADGLEPGPGLLHGETGSKKKIRLYQFLLD 180
181 LLRSGDMKDSIWWVDKDKGTFQFSSKHKEALAHRWGIQKGNRKKMTYQKMARALRNYGKT 240
241 GEVKKVKKKLTYQFSGEVLGRGGLAERRLPPH
Interface Residues: 28, 228, 229, 231, 232, 233, 235, 236, 249
3D-footprint Homologues: 4uzb_B, 3zp5_A, 7jsa_J, 4mhg_A, 2stt_A, 8ee9_F, 4uno_A, 3jtg_A, 1dux_F, 4lg0_B, 1yo5_C, 4bqa_A, 1awc_A, 4iri_A, 1bc8_C, 4l18_B
Binding Motifs: PB0162.1 maawttmvgGAAcc
MA0080.3 rraaagAGGAAGTGr
M0685_1.02 wwrvGGAAst
SPI1_MOUSE.H10MO.A|M01356 arAAAGrGGAAGTGva
PB0058.1 ydawgvGGAAsTdm
MA0080.6 rraAAGAGGAAGTGgra
MA0080.7 aAAGAGGAAGTGg
Binding Sites: MA0080.3.1
MA0080.3.10
MA0080.3.11
MA0080.3.12
MA0080.3.13
MA0080.3.14
MA0080.3.15
MA0080.3.16
MA0080.3.17
MA0080.3.18
MA0080.3.19
MA0080.3.2
MA0080.3.20
MA0080.3.3
MA0080.3.4
MA0080.3.5
MA0080.3.6
MA0080.3.7
MA0080.3.8
MA0080.3.9
MA0080.6.1 / MA0080.6.6
MA0080.6.10
MA0080.6.11
MA0080.6.12
MA0080.6.13
MA0080.6.14
MA0080.6.15
MA0080.6.16
MA0080.6.17
MA0080.6.18
MA0080.6.19
MA0080.6.2 / MA0080.6.9
MA0080.6.20
MA0080.6.13 / MA0080.6.3
MA0080.6.15 / MA0080.6.4
MA0080.6.16 / MA0080.6.5
MA0080.6.18 / MA0080.6.6
MA0080.6.7
MA0080.6.8
MA0080.6.9
MA0080.6.1
MA0080.6.10
MA0080.6.11
MA0080.6.12
MA0080.6.14
MA0080.6.17
MA0080.6.19
MA0080.6.2
MA0080.6.20
MA0080.6.3
MA0080.6.4
MA0080.6.5
MA0080.6.7
MA0080.6.8
MA0080.7.1
MA0080.7.10
MA0080.7.11
MA0080.7.12
MA0080.7.13
MA0080.7.14
MA0080.7.15
MA0080.7.16 / MA0080.7.9
MA0080.7.17
MA0080.7.18
MA0080.7.19
MA0080.7.2
MA0080.7.20
MA0080.7.3
MA0080.7.4
MA0080.7.5
MA0080.7.6
MA0080.7.7
MA0080.7.8
Publications: Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed]

Portales-Casamar E, Kirov S, Lim J, Lithwick S, Swanson M.I, Ticoll A, Snoddy J, Wasserman W.W. PAZAR: a framework for collection and dissemination of cis-regulatory sequence annotation. Genome biology 8:R207 (2007). [Pubmed]

Ray-Gallet D, Mao C, Tavitian A, Moreau-Gachelin F. DNA binding specificities of Spi-1/PU.1 and Spi-B transcription factors and identification of a Spi-1/Spi-B binding site in the c-fes/c-fps promoter. Oncogene 11:303-13 (1995). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.