Transcription Factor

						

			
Accessions: O43316 (JASPAR 2024)

			
Names: PAX4_HUMAN
Organisms: Homo sapiens
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Length: 350
Pfam Domains:     7-129 'Paired box' domain
  172-227 Homeobox domain
Sequence: 
(in bold interface residues)		   1 MHQDGISSMNQLGGLFVNGRPLPLDTRQQIVRLAVSGMRPCDISRILKVSNGCVSKILGR   60
  61 YYRTGVLEPKGIGGSKPRLATPPVVARIAQLKGECPALFAWEIQRQLCAEGLCTQDKTPS  120
 121 VSSINRVLRALQEDQGLPCTRLRSPAVLAPAVLTPHSGSETPRGTHPGTGHRNRTIFSPS  180
 181 QAEALEKEFQRGQYPDSVARGKLATATSLPEDTVRVWFSNRRAKWRRQEKLKWEMQLPGA  240
 241 SQGLTVPRVAPGIISAQQSPGSVPTAALPALEPLGPSCYQLCWATAPERCLSDTPPKACL  300
 301 KPCWDCGSFLLPVIAPSCVDVAWPCLDASLAHHLIGGAGKATPTHFSHWP
Interface Residues: 18, 50, 51, 53, 55, 56, 72, 75, 78, 120, 121, 122, 123, 125, 126, 129, 169, 171, 172, 173, 174, 212, 213, 215, 216, 219, 220, 223, 224, 227
3D-footprint Homologues: 1pdn_C, 6pax_A, 1k78_A, 1mnm_C, 3d1n_M, 5zfz_A, 1le8_B, 1k61_B, 1puf_A, 6a8r_A, 1nk2_P, 1jgg_B, 1zq3_P, 6m3d_C, 3lnq_A, 2lkx_A, 6es3_K, 2ld5_A, 7q3o_C, 2hdd_A, 1ig7_A, 5jlw_D, 3rkq_B, 2r5y_A, 1puf_B, 4xrs_G, 2hos_A, 7psx_B, 4cyc_A, 5flv_I, 5zjt_E, 1au7_A, 3a01_E, 2h1k_B, 1fjl_B, 5hod_A, 1b72_A, 3cmy_A, 1le8_A, 2xsd_C, 1e3o_C, 7xrc_C, 6wig_A, 8g87_X, 1du0_A, 1o4x_A, 3l1p_A, 4qtr_D, 4j19_B
Binding Motifs: MA0068.2 ctAATTAg
			
Publications: Smith S. B., Ee H. C., Conners  J. R., German M. S. Paired-homeodomain transcription factor PAX4 acts as a transcriptional repressor in early pancreatic development. Mol. Cell. Biol. 19:8272-8280 (1999). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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