Transcription Factor
| Accessions: | REST_HUMAN (HOCOMOCO 10), NP_005603 (JASPAR 2024), Q13127 (JASPAR 2024) |
| Names: | Neural-restrictive silencer factor, RE1-silencing transcription factor, REST_HUMAN, X2 box repressor |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 1098 |
| Pfam Domains: | 217-238 C2H2-type zinc finger 276-298 C2H2-type zinc-finger domain 290-314 Zinc-finger double domain 304-326 Zinc finger, C2H2 type 304-327 C2H2-type zinc-finger domain 304-326 C2H2-type zinc finger 318-343 Zinc-finger double domain 332-356 C2H2-type zinc-finger domain 332-355 C2H2-type zinc finger 348-370 Zinc-finger double domain 362-383 C2H2-type zinc-finger domain 375-399 Zinc-finger double domain |
| Sequence: (in bold interface residues) | 1 MATQVMGQSSGGGGLFTSSGNIGMALPNDMYDLHDLSKAELAAPQLIMLANVALTGEVNG 60 61 SCCDYLVGEERQMAELMPVGDNNFSDSEEGEGLEESADIKGEPHGLENMELRSLELSVVE 120 121 PQPVFEASGAPDIYSSNKDLPPETPGAEDKGKSSKTKPFRCKPCQYEAESEEQFVHHIRV 180 181 HSAKKFFVEESAEKQAKARESGSSTAEEGDFSKGPIRCDRCGYNTNRYDHYTAHLKHHTR 240 241 AGDNERVYKCIICTYTTVSEYHWRKHLRNHFPRKVYTCGKCNYFSDRKNNYVQHVRTHTG 300 301 ERPYKCELCPYSSSQKTHLTRHMRTHSGEKPFKCDQCSYVASNQHEVTRHARQVHNGPKP 360 361 LNCPHCDYKTADRSNFKKHVELHVNPRQFNCPVCDYAASKKCNLQYHFKSKHPTCPNKTM 420 421 DVSKVKLKKTKKREADLPDNITNEKTEIEQTKIKGDVAGKKNEKSVKAEKRDVSKEKKPS 480 481 NNVSVIQVTTRTRKSVTEVKEMDVHTGSNSEKFSKTKKSKRKLEVDSHSLHGPVNDEESS 540 541 TKKKKKVESKSKNNSQEVPKGDSKVEENKKQNTCMKKSTKKKTLKNKSSKKSSKPPQKEP 600 601 VEKGSAQMDPPQMGPAPTEAVQKGPVQVEPPPPMEHAQMEGAQIRPAPDEPVQMEVVQEG 660 661 PAQKELLPPVEPAQMVGAQIVLAHMELPPPMETAQTEVAQMGPAPMEPAQMEVAQVESAP 720 721 MQVVQKEPVQMELSPPMEVVQKEPVQIELSPPMEVVQKEPVKIELSPPIEVVQKEPVQME 780 781 LSPPMGVVQKEPAQREPPPPREPPLHMEPISKKPPLRKDKKEKSNMQSERARKEQVLIEV 840 841 GLVPVKDSWLLKESVSTEDLSPPSPPLPKENLREEASGDQKLLNTGEGNKEAPLQKVGAE 900 901 EADESLPGLAANINESTHISSSGQNLNTPEGETLNGKHQTDSIVCEMKMDTDQNTRENLT 960 961 GINSTVEEPVSPMLPPSAVEEREAVSKTALASPPATMAANESQEIDEDEGIHSHEG SDL 1020 1021 SDNMSEGSDDSGLHGARPVPQESSRKNAKEALAVKAAKGDFVCIFCDRSFRKGKDYSKHL 1080 1081 NRHLVNVYYLEEAAQGQE |
| Interface Residues: | 199, 201, 202, 205, 227, 228, 229, 233, 256, 257, 258, 259, 260, 261, 262, 264, 265, 276, 284, 285, 286, 287, 288, 289, 290, 291, 293, 295, 296, 297, 299, 314, 315, 316, 317, 318, 320, 321, 322, 325, 342, 343, 344, 345, 346, 347, 348, 349, 350, 353, 355, 358, 372, 373, 374, 375, 376, 377, 378, 396, 398, 399, 400, 401, 402, 403, 406, 409 |
| 3D-footprint Homologues: | 5v3j_F, 7w1m_H, 2drp_D, 5kkq_D, 7ysf_A, 2lt7_A, 2i13_A, 5yel_A, 7eyi_G, 2kmk_A, 6jnm_A, 1tf3_A, 8cuc_F, 7y3l_A, 1f2i_J, 8ssq_A, 1g2f_F, 8ssu_A, 1tf6_A, 6ml4_A, 4x9j_A, 6u9q_A, 5ei9_F, 1mey_C, 3uk3_C, 7y3m_I, 6wmi_A, 6a57_A, 7n5w_A, 1ubd_C, 2jpa_A, 8h9h_G, 5yj3_D, 5k5i_A, 5und_A, 2gli_A, 1llm_D, 6blw_A, 2wbs_A, 7txc_E, 5kl3_A, 4m9v_C, 6e94_A, 8gn3_A, 5k5l_F |
| Binding Motifs: | MA0138.2 tTCAGcACCatGGACAGckcC REST_HUMAN.H10MO.A|M01480 tTCAGcACCayGGACAGCkcCm MA0138.1 GmGCTGTCCatGGTGCTGA MA0138.3 TCAGcACCatGGACAGckcC |
| Binding Sites: | MA0138.1.1 MA0138.1.10 MA0138.1.11 MA0138.1.12 MA0138.1.13 MA0138.1.14 MA0138.1.15 MA0138.1.16 MA0138.1.17 MA0138.1.18 MA0138.1.19 MA0138.1.2 MA0138.1.20 MA0138.1.3 MA0138.1.4 MA0138.1.5 MA0138.1.6 MA0138.1.7 MA0138.1.8 MA0138.1.9 MA0138.2.1 MA0138.2.10 MA0138.2.11 MA0138.2.12 MA0138.2.13 MA0138.2.14 MA0138.2.15 MA0138.2.16 MA0138.2.17 MA0138.2.18 MA0138.2.19 MA0138.2.2 MA0138.2.20 MA0138.2.3 MA0138.2.4 MA0138.2.5 MA0138.2.6 MA0138.2.7 MA0138.2.8 MA0138.2.9 |
| Publications: | Johnson D.S, Mortazavi A, Myers R.M, Wold B. Genome-wide mapping of in vivo protein-DNA interactions. Science (New York, N.Y.) 316:1497-502 (2007). [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.