Transcription Factor

Accessions: T098522_1.02 (CISBP 1.02), Q8IRC7 (JASPAR 2024)
Names: Awh, T098522_1.02;, AWH_DROME, LIM/homeobox protein Awh, Protein arrowhead
Organisms: Drosophila melanogaster
Libraries: CISBP 1.02 1, JASPAR 2024 2
1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot: Q8IRC7
Notes: experiment type:PBM, family:Homeodomain
Length: 275
Pfam Domains: 8-65 LIM domain
69-125 LIM domain
149-205 Homeobox domain
Sequence:
(in bold interface residues)
1 MKTELRSCAACGEPISDRFFLEVGGCSWHAHCLRCCMCMCPLDRQQSCFIRERQVYCKAD 60
61 YSKNFGAKCSKCCRGISASDWVRRARELVFHLACFACDQCGRQLSTGEQFALMDDRVLCK 120
121 AHYLETVEGGTTSSDEGCDGDGYHKSKTKRVRTTFTEEQLQVLQANFQIDSNPDGQDLER 180
181 IASVTGLSKRVTQVWFQNSRARQKKHIHAGKNKIREPEGSSFARHINLQLTYSFQNNAQN 240
241 PMHLNGSKAGLYPTHESSMDELSQDSSVHCMPSEV
Interface Residues: 78, 80, 87, 90, 106, 108, 109, 149, 150, 151, 152, 190, 191, 193, 194, 197, 198, 201, 202, 205
3D-footprint Homologues: 1llm_D, 1puf_A, 3d1n_M, 1fjl_B, 6a8r_A, 1ig7_A, 1nk2_P, 3cmy_A, 2h1k_B, 5zfz_A, 2lkx_A, 6m3d_C, 1zq3_P, 3lnq_A, 1jgg_B, 7q3o_C, 2ld5_A, 6es3_K, 5flv_I, 2hdd_A, 1au7_A, 5zjt_E, 4cyc_A, 2r5y_A, 1puf_B, 7psx_B, 5hod_A, 3l1p_A, 2hos_A, 1b72_A, 3a01_E, 5jlw_D, 4xrs_G, 3rkq_B, 1e3o_C, 1le8_A, 4qtr_D, 1du0_A
Binding Motifs: MA0167.1 yTAATTA
M1097_1.02 ryTAATTAry
Binding Sites: MA0167.1.1
MA0167.1.10
MA0167.1.11
MA0167.1.12
MA0167.1.13
MA0167.1.14
MA0167.1.15
MA0167.1.16
MA0167.1.17
MA0167.1.18
MA0167.1.19
MA0167.1.2
MA0167.1.20
MA0167.1.3
MA0167.1.4
MA0167.1.5
MA0167.1.6
MA0167.1.7
MA0167.1.8
MA0167.1.9
Publications: Noyes M.B, Meng X, Wakabayashi A, Sinha S, Brodsky M.H, Wolfe S.A. A systematic characterization of factors that regulate Drosophila segmentation via a bacterial one-hybrid system. Nucleic acids research 36:2547-60 (2008). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.