Transcription Factor

Accessions: zen (DrosophilaTF 1.1), P09089 (JASPAR 2024)
Names: Protein zerknuellt 1, ZEN-1, ZEN1_DROME
Organisms: Drosophila melanogaster
Libraries: DrosophilaTF 1.1 1, JASPAR 2024 2
1 Down T.A, Bergman C.M, Su J, Hubbard T.J. Large-scale discovery of promoter motifs in Drosophila melanogaster. PLoS computational biology 3:e7 (2007). [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Length: 353
Pfam Domains: 91-147 Homeobox domain
Sequence:
(in bold interface residues)
1 MSSVMHYYPVHQAKVGSYSADPSEVKYSDLIYGHHHDVNPIGLPPNYNQMNSNPTTLNDH 60
61 CSPQHVHQQHVSSDENLPSQPNHDSQRVKLKRSRTAFTSVQLVELENEFKSNMYLYRTRR 120
121 IEIAQRLSLCERQVKIWFQNRRMKFKKDIQGHREPKSNAKLAQPQAEQSAHRGIVKRLMS 180
181 YSQDPREGTAAAEKRPMMAVAPVNPKPDYQASQKMKTEASTNNGMCSSADLSEILEHLAQ 240
241 TTAAPQVSTATSSTGTSTNSASSSSSGHYSYNVDLVLQSIKQDLEAAAQAWSKSKSAPIL 300
301 ATQSWHPSSQSQVPTSVHAAPSMNLSWGEPAAKSRKLSVNHMNPCVTSYNYPN
Interface Residues: 91, 92, 93, 94, 132, 133, 135, 136, 139, 140, 143, 144, 147
3D-footprint Homologues: 3d1n_M, 5zfz_A, 1fjl_B, 6a8r_A, 3cmy_A, 2h1k_B, 1ig7_A, 1puf_A, 1jgg_B, 6m3d_C, 1zq3_P, 3lnq_A, 1nk2_P, 2lkx_A, 2ld5_A, 7q3o_C, 6es3_K, 2hdd_A, 4cyc_A, 2r5y_A, 1puf_B, 5flv_I, 2hos_A, 5zjt_E, 4j19_B, 3a01_E, 7psx_B, 5hod_A, 1b72_A, 5jlw_D, 3rkq_B, 4xrs_G, 1e3o_C, 1le8_A, 8g87_X, 3l1p_A, 4qtr_D, 1du0_A
Binding Motifs: MA0256.1 yTAATKA
zen TCAwTTAAmT
Binding Sites: MA0256.1.1
MA0256.1.13
MA0256.1.17
MA0256.1.11
MA0256.1.16
MA0256.1.18
MA0256.1.14 / MA0256.1.7
MA0256.1.10
MA0256.1.15
MA0256.1.3
MA0256.1.12 / MA0256.1.9
MA0256.1.19
MA0256.1.2
MA0256.1.4
MA0256.1.5
MA0256.1.6
MA0256.1.8
Publications: Hoey T., Levine M. Divergent homeo box proteins recognize similar DNA sequences in Drosophila. Nature 332:858-861 (1988). [Pubmed]

Noyes M.B, Meng X, Wakabayashi A, Sinha S, Brodsky M.H, Wolfe S.A. A systematic characterization of factors that regulate Drosophila segmentation via a bacterial one-hybrid system. Nucleic acids research 36:2547-60 (2008). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.