Transcription Factor
| Accessions: | Q8NAM6 (JASPAR 2024) |
| Names: | Zinc finger and SCAN domain-containing protein 4, Zinc finger protein 494, ZSCA4_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q8NAM6 |
| Length: | 433 |
| Pfam Domains: | 40-129 SCAN domain 301-323 Zinc-finger double domain 312-334 C2H2-type zinc finger 312-334 Zinc finger, C2H2 type 326-349 Zinc-finger double domain 340-362 Zinc finger, C2H2 type 340-362 C2H2-type zinc finger 354-379 Zinc-finger double domain 368-390 Zinc finger, C2H2 type 368-390 C2H2-type zinc finger 382-405 Zinc-finger double domain 396-418 Zinc finger, C2H2 type 396-418 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 MALDLRTIFQCEPSENNLGSENSAFQQSQGPAVQREEGISEFSRMVLNSFQDSNNSYARQ 60 61 ELQRLYRIFHSWLQPEKHSKDEIISLLVLEQFMIGGHCNDKASVKEKWKSSGKNLERFIE 120 121 DLTDDSINPPALVHVHMQGQEALFSEDMPLRDVIVHLTKQVNAQTTREANMGTPSQTSQD 180 181 TSLETGQGYEDEQDGWNSSSKTTRVNENITNQGNQIVSLIIIQEENGPRPEEGGVSSDNP 240 241 YNSKRAELVTARSQEGSINGITFQGVPMVMGAGCISQPEQSSPESALTHQSNEGNSTCEV 300 301 HQKGSHGVQKSYKCEECPKVFKYLCHLLAHQRRHRNERPFVCPECQKGFFQISDLRVHQI 360 361 IHTGKKPFTCSMCKKSFSHKTNLRSHERIHTGEKPYTCPFCKTSYRQSSTYHRHMRTHEK 420 421 ITLPSVPSTPEAS |
| Interface Residues: | 312, 322, 323, 324, 325, 326, 328, 329, 331, 332, 335, 350, 351, 352, 353, 354, 356, 357, 360, 378, 379, 380, 381, 382, 383, 384, 385, 386, 388, 389, 393, 406, 407, 408, 409, 410, 411, 412, 413, 414 |
| 3D-footprint Homologues: | 2kmk_A, 1tf3_A, 7w1m_H, 5v3j_F, 2drp_D, 6wmi_A, 8ssq_A, 2gli_A, 8ssu_A, 2i13_A, 5kkq_D, 5ei9_F, 7eyi_G, 6e94_A, 7ysf_A, 2jpa_A, 1ubd_C, 6jnm_A, 8cuc_F, 7y3l_A, 7n5w_A, 5kl3_A, 1g2f_F, 5und_A, 5k5l_F, 6ml4_A, 4x9j_A, 8gn3_A, 1mey_C, 6blw_A, 1f2i_J, 5yel_A, 8h9h_G, 1tf6_A, 2lt7_A, 7y3m_I, 6a57_A, 3uk3_C, 7txc_E, 5yj3_D, 5k5i_A, 1llm_D, 2wbs_A, 6u9q_A, 4m9v_C, 1yuj_A |
| Binding Motifs: | MA1155.1 tGCACACmCTGaAAa |
| Binding Sites: | MA1155.1.1 / MA1155.1.2 MA1155.1.10 MA1155.1.11 MA1155.1.12 MA1155.1.13 MA1155.1.14 MA1155.1.15 MA1155.1.16 MA1155.1.17 MA1155.1.18 MA1155.1.19 MA1155.1.20 MA1155.1.3 MA1155.1.4 MA1155.1.5 MA1155.1.6 MA1155.1.7 MA1155.1.8 MA1155.1.9 |
| Publications: | Isakova A, Groux R, Imbeault M, Rainer P, Alpern D, Dainese R, Ambrosini G, Trono D, Bucher P, Deplancke B. SMiLE-seq identifies binding motifs of single and dimeric transcription factors. Nat Methods 14:316-322 (2017). [Pubmed] |
| Related annotations: | PaperBLAST |
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