Transcription Factor
Accessions: | RUNX3_HUMAN (HOCOMOCO 10), Q13761 (JASPAR 2024) |
Names: | Acute myeloid leukemia 2 protein, CBF-alpha-3, Core-binding factor subunit alpha-3, Oncogene AML-2, PEA2-alpha C, PEBP2-alpha C, Polyomavirus enhancer-binding protein 2 alpha C subunit, Runt-related transcription factor 3, RUNX3_HUMAN, SL3-3 enhancer factor 1 alpha C subunit, SL3/AKV core-binding factor alpha C subunit |
Organisms: | Homo sapiens |
Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
Length: | 415 |
Pfam Domains: | 53-186 Runt domain 313-415 Runx inhibition domain |
Sequence: (in bold interface residues) | 1 MRIPVDPSTSRRFTPPSPAFPCGGGGGKMGENSGALSAQAAVGPGGRARPEVRSMVDVLA 60 61 DHAGELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTVVTVMAGNDENYSAE 120 121 LRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPTQVATYHRAIKVTVDGPREP 180 181 RRHRQKLEDQTKPFPDRFGDLERLRMRVTPSTPSPRGSLSTTSHFSSQPQTPIQGTSELN 240 241 PFSDPRQFDRSFPTLPTLTESRFPDPRMHYPGAMSAAFPYSATPSGTSISSLSVAGMPAT 300 301 SRFHHTYLPPPYPGAPQNQSGPFQANPSPYHLYYGTSSGSYQFSMVAGSSSGGDRSPTRM 360 361 LASCTSSAASVAAGNLMNPSLGGQSDGVEADGSHSNSPTALSTPGRMDEAVWRPY |
Interface Residues: | 84, 146, 174, 175, 178, 181 |
3D-footprint Homologues: | 6vgd_D, 4l0y_A, 4l18_E, 6vg8_D, 3wts_A |
Binding Motifs: | MA0684.1 wAACCrCAaa RUNX3_HUMAN.H10MO.C|M01492 ktyTGTGGTTw MA0684.2 awAACCTCAawh MA0684.3 AACCTCAa |
Binding Sites: | MA0684.3.12 / MA0684.3.5 / MA0684.3.7 MA0684.2.1 MA0684.2.10 MA0684.2.11 MA0684.2.12 / MA0684.2.4 MA0684.2.13 MA0684.2.14 / MA0684.2.5 MA0684.2.15 / MA0684.2.6 MA0684.2.16 / MA0684.2.7 MA0684.2.17 / MA0684.2.8 MA0684.2.18 / MA0684.2.9 MA0684.2.10 / MA0684.2.19 MA0684.2.1 / MA0684.2.2 MA0684.2.11 / MA0684.2.20 MA0684.2.3 MA0684.2.4 MA0684.2.5 MA0684.2.3 / MA0684.2.6 MA0684.2.7 MA0684.2.8 MA0684.2.9 MA0684.2.12 MA0684.2.13 MA0684.2.14 MA0684.2.15 MA0684.2.16 MA0684.2.17 MA0684.2.18 MA0684.2.19 / MA0684.2.20 MA0684.2.2 MA0684.3.1 MA0684.3.10 MA0684.3.11 / MA0684.3.6 MA0684.3.13 MA0684.3.14 / MA0684.3.4 MA0684.3.15 / MA0684.3.19 / MA0684.3.20 MA0684.3.16 / MA0684.3.8 MA0684.3.17 MA0684.3.18 MA0684.3.2 MA0684.3.3 MA0684.3.9 |
Publications: | Bowers S. R., Calero-Nieto F. J., Valeaux S., Fernandez-Fuentes N., Cockerill P. N. Runx1 binds as a dimeric complex to overlapping Runx1 sites within a palindromic element in the human GM-CSF enhancer.. Nucleic Acids Res. 38:6124-6134 (2010). [Pubmed] Jolma A., Kivioja T., Toivonen J., Cheng L., Wei G., Enge M., Taipale M., Vaquerizas J. M., Yan J., Sillanpaa M. J., Bonke M., Palin K., Talukder S., Hughes T. R., Luscombe N. M., Ukkonen E., Taipale J. Multiplexed massively parallel SELEX for characterization of human transcription factor binding specificities.. Genome Res. 20:861-873 (2010). [Pubmed] |
Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.