Transcription Factor

Accessions: RUNX3_HUMAN (HOCOMOCO 10), Q13761 (JASPAR 2024)
Names: Acute myeloid leukemia 2 protein, CBF-alpha-3, Core-binding factor subunit alpha-3, Oncogene AML-2, PEA2-alpha C, PEBP2-alpha C, Polyomavirus enhancer-binding protein 2 alpha C subunit, Runt-related transcription factor 3, RUNX3_HUMAN, SL3-3 enhancer factor 1 alpha C subunit, SL3/AKV core-binding factor alpha C subunit
Organisms: Homo sapiens
Libraries: HOCOMOCO 10 1, JASPAR 2024 2
1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Length: 415
Pfam Domains: 53-186 Runt domain
313-415 Runx inhibition domain
Sequence:
(in bold interface residues)
1 MRIPVDPSTSRRFTPPSPAFPCGGGGGKMGENSGALSAQAAVGPGGRARPEVRSMVDVLA 60
61 DHAGELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTVVTVMAGNDENYSAE 120
121 LRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPTQVATYHRAIKVTVDGPREP 180
181 RRHRQKLEDQTKPFPDRFGDLERLRMRVTPSTPSPRGSLSTTSHFSSQPQTPIQGTSELN 240
241 PFSDPRQFDRSFPTLPTLTESRFPDPRMHYPGAMSAAFPYSATPSGTSISSLSVAGMPAT 300
301 SRFHHTYLPPPYPGAPQNQSGPFQANPSPYHLYYGTSSGSYQFSMVAGSSSGGDRSPTRM 360
361 LASCTSSAASVAAGNLMNPSLGGQSDGVEADGSHSNSPTALSTPGRMDEAVWRPY
Interface Residues: 84, 146, 174, 175, 178, 181
3D-footprint Homologues: 6vgd_D, 4l0y_A, 4l18_E, 6vg8_D, 3wts_A
Binding Motifs: MA0684.1 wAACCrCAaa
RUNX3_HUMAN.H10MO.C|M01492 ktyTGTGGTTw
MA0684.2 awAACCTCAawh
MA0684.3 AACCTCAa
Binding Sites: MA0684.3.12 / MA0684.3.5 / MA0684.3.7
MA0684.2.1
MA0684.2.10
MA0684.2.11
MA0684.2.12 / MA0684.2.4
MA0684.2.13
MA0684.2.14 / MA0684.2.5
MA0684.2.15 / MA0684.2.6
MA0684.2.16 / MA0684.2.7
MA0684.2.17 / MA0684.2.8
MA0684.2.18 / MA0684.2.9
MA0684.2.10 / MA0684.2.19
MA0684.2.1 / MA0684.2.2
MA0684.2.11 / MA0684.2.20
MA0684.2.3
MA0684.2.4
MA0684.2.5
MA0684.2.3 / MA0684.2.6
MA0684.2.7
MA0684.2.8
MA0684.2.9
MA0684.2.12
MA0684.2.13
MA0684.2.14
MA0684.2.15
MA0684.2.16
MA0684.2.17
MA0684.2.18
MA0684.2.19 / MA0684.2.20
MA0684.2.2
MA0684.3.1
MA0684.3.10
MA0684.3.11 / MA0684.3.6
MA0684.3.13
MA0684.3.14 / MA0684.3.4
MA0684.3.15 / MA0684.3.19 / MA0684.3.20
MA0684.3.16 / MA0684.3.8
MA0684.3.17
MA0684.3.18
MA0684.3.2
MA0684.3.3
MA0684.3.9
Publications: Bowers S. R., Calero-Nieto F. J., Valeaux S., Fernandez-Fuentes N., Cockerill P. N. Runx1 binds as a dimeric complex to overlapping Runx1 sites within a palindromic element in the human GM-CSF enhancer.. Nucleic Acids Res. 38:6124-6134 (2010). [Pubmed]

Jolma A., Kivioja T., Toivonen J., Cheng L., Wei G., Enge M., Taipale M., Vaquerizas J. M., Yan J., Sillanpaa M. J., Bonke M., Palin K., Talukder S., Hughes T. R., Luscombe N. M., Ukkonen E., Taipale J. Multiplexed massively parallel SELEX for characterization of human transcription factor binding specificities.. Genome Res. 20:861-873 (2010). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.