Transcription Factor
Accessions: | ECK120004565 (RegulonDB 7.5) |
Names: | AsnC |
Organisms: | ECK12 |
Libraries: | RegulonDB 7.5 1 1 Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muniz-Rascado L, Garcia-Sotelo JS, Weiss V, Solano-Lira H, Martinez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernandez S, Alquicira-Hernandez K, Lopez-Fuentes A, Porron-Sotelo L, Huerta AM, Bonavides-Martinez C, Balderas-Martinez YI, Pannier L, Olvera M, Labastida A, Jimenez-Jacinto V, Vega-Alvarado L, Del Moral-Chavez V, Hernandez-Alvarez A, Morett E, Collado-Vides J. RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more. Nucleic Acids Res. 2013 Jan 1;41(D1):D203-D213. [Pubmed] |
Notes: | cytoplasm; regulon; positive regulation of transcription, DNA-dependent; negative regulation of transcription, DNA-dependent; response to amino acid stimulus; amino acid binding; sequence-specific DNA binding; intracellular; sequence-specific DNA binding transcription factor activity; transcription activator activity; asparagine; Transcription related; activator; repressor; specific transcriptional repressor activity |
Length: | 153 |
Pfam Domains: | 6-47 AsnC-type helix-turn-helix domain 6-53 Winged helix-turn-helix DNA-binding 24-66 HTH domain 75-143 AsnC family |
Sequence: (in bold interface residues) | 1 MENYLIDNLDRGILEALMGNARTAYAELAKQFGVSPGTIHVRVEKMKQAGIITGARIDVS 60 61 PKQLGYDVGCFIGIILKSAKDYPSALAKLESLDEVTEAYYTTGHYSIFIKVMCRSIDALQ 120 121 HVLINKIQTIDEIQSTETLIVLQNPIMRTIKP* |
Interface Residues: | 25, 35, 36, 37, 38, 40, 45, 62 |
3D-footprint Homologues: | 2e1c_A, 5haw_A, 1z9c_A |
Binding Motifs: | AsnC KKWTTrwTGMwT |
Binding Sites: | ECK120048773 ECK120048775 ECK120048792 ECK120048794 |
Publications: | Kolling R., Lother H. AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli. J Bacteriol. 164(1):310-5 (1985). [Pubmed] de Wind N., de Jong M., Meijer M., Stuitje AR. Site-directed mutagenesis of the Escherichia coli chromosome near oriC: identification and characterization of asnC, a regulatory element in E. coli asparagine metabolism. Nucleic Acids Res. 13(24):8797-811 (1985). [Pubmed] Perez-Rueda E., Collado-Vides J. Common history at the origin of the position-function correlation in transcriptional regulators in archaea and bacteria. J Mol Evol. 53(3):172-9 (2001). [Pubmed] Thaw P., Sedelnikova SE., Muranova T., Wiese S., Ayora S., Alonso JC., Brinkman AB., Akerboom J., van der Oost J., Rafferty JB. Structural insight into gene transcriptional regulation and effector binding by the Lrp/AsnC family. Nucleic Acids Res. 34(5):1439-1449 (2006). [Pubmed] Yokoyama K., Ishijima SA., Clowney L., Koike H., Aramaki H., Tanaka C., Makino K., Suzuki M. Feast/famine regulatory proteins (FFRPs): Escherichia coli Lrp, AsnC and related archaeal transcription factors. FEMS Microbiol Rev. 30(1):89-108 (2006). [Pubmed] Kolling R., Gielow A., Seufert W., Kucherer C., Messer W. AsnC, a multifunctional regulator of genes located around the replication origin of Escherichia coli, oriC. Mol Gen Genet. 212(1):99-104 (1988). [Pubmed] Gielow A., Kucherer C., Kolling R., Messer W. Transcription in the region of the replication origin, oriC, of Escherichia coli: termination of asnC transcripts. Mol Gen Genet. 214(3):474-81 (1988). [Pubmed] Schaefer C., Messer W. Termination of the Escherichia coli asnC transcript. The DnaA protein/dnaA box complex blocks transcribing RNA polymerase. Gene. 73(2):347-54 (1988). [Pubmed] Poggio S., Domeinzain C., Osorio A., Camarena L. The nitrogen assimilation control (Nac) protein represses asnC and asnA transcription in Escherichia coli. FEMS Microbiol Lett. 206(2):151-6 (2002). [Pubmed] |
Related annotations: | PaperBLAST |
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