Transcription Factor
| Accessions: | Q9Y5J3 (JASPAR 2024) |
| Names: | bHLHb31, Cardiovascular helix-loop-helix factor 2, CHF-2, Class B basic helix-loop-helix protein 31, Hairy and enhancer of split-related protein 1, Hairy-related transcription factor 1, Hairy/enhancer-of-split related with YRPW motif protein 1, HES-related repressor protein 1, HESR-1, HEY1_HUMAN, hHRT1, HRT-1 |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q9Y5J3 |
| Length: | 304 |
| Pfam Domains: | 53-104 Helix-loop-helix DNA-binding domain 122-164 Hairy Orange |
| Sequence: (in bold interface residues) | 1 MKRAHPEYSSSDSELDETIEVEKESADENGNLSSALGSMSPTTSSQILARKRRRGIIEKR 60 61 RRDRINNSLSELRRLVPSAFEKQGSAKLEKAEILQMTVDHLKMLHTAGGKGYFDAHALAM 120 121 DYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSHLNNYASQREAASGAHAGLGHIPW 180 181 GTVFGHHPHIAHPLLLPQNGHGNAGTTASPTEPHHQGRLGSAHPEAPALRAPPSGSLGPV 240 241 LPVVTSASKLSPPLLSSVASLSAFPFSFGSFHLLSPNALSPSAPTQAANLGKPYRPWGTE 300 301 IGAF |
| Interface Residues: | 42, 43, 45, 51, 53, 54, 55, 57, 58, 61, 62, 83, 88 |
| 3D-footprint Homologues: | 3e6c_C, 7z5k_B, 1an4_A, 6g1l_A, 5eyo_A, 5sy7_B, 4h10_B, 7f2f_B, 8osl_O, 7ssa_L, 7d8t_A, 2ql2_D, 7xi3_A, 4h10_A, 1am9_A, 8osl_P, 5gnj_I, 5v0l_A, 1a0a_B, 2ypa_A, 4zpk_A, 5nj8_D, 5nj8_C, 5v0l_B |
| Binding Motifs: | MA0823.1 grCACGTGyc |
| Publications: | Heisig J, Weber D, Englberger E, Winkler A, Kneitz S, Sung WK, Wolf E, Eilers M, Wei CL, Gessler M. Target gene analysis by microarrays and chromatin immunoprecipitation identifies HEY proteins as highly redundant bHLH repressors. PLoS Genet : (2012;8(5):e1002728.). [Pubmed] |
| Related annotations: | PaperBLAST |
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