Transcription Factor
| Accessions: | P61375 (JASPAR 2024) |
| Names: | LHX5_MOUSE, LIM homeobox protein 5, LIM/homeobox protein Lhx5 |
| Organisms: | Mus musculus, Rattus norvegicus |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 402 |
| Pfam Domains: | 5-60 LIM domain 64-121 LIM domain 181-237 Homeobox domain 203-232 Homeobox KN domain |
| Sequence: (in bold interface residues) | 1 MMVHCAGCERPILDRFLLNVLDRAWHIKCVQCCECKTNLSEKCFSREGKLYCKNDFFRRF 60 61 GTKCAGCAQGISPSDLVRKARSKVFHLNCFTCMVCNKQLSTGEELYVIDENKFVCKDDYL 120 121 SSSSLKEGSLNSVSSCTDRSLSPDLQDPLQDDPKETDNSTSSDKETANNENEEQNSGTKR 180 181 RGPRTTIKAKQLETLKAAFAATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSKERRMKQ 240 241 LSALGARRHAFFRSPRRMRPLGGRLDESEMLGSTPYTYYGDYQSDYYAPGGNYDFFAHGP 300 301 PSQAQSPADSSFLAASGPGSTPLGALEPPLAGPHGADNPRFTDMISHPDTPSPEPGLPGA 360 361 LHPMPGEVFSGGPSPPFPMSGTSGYSGPLSHPNPELNEAAVW |
| Interface Residues: | 178, 180, 181, 182, 183, 184, 222, 223, 225, 226, 229, 230, 233, 234, 236, 237, 247 |
| 3D-footprint Homologues: | 1puf_A, 2ld5_A, 4j19_B, 3a01_E, 2lkx_A, 1ig7_A, 5zjt_E, 3cmy_A, 1mnm_C, 7psx_B, 6a8r_A, 3d1n_M, 1fjl_B, 5zfz_A, 1nk2_P, 1zq3_P, 5jlw_D, 1k61_B, 2h1k_B, 6m3d_C, 1b72_A, 5flv_I, 3lnq_A, 2hdd_A, 5hod_A, 3rkq_B, 2r5y_A, 1puf_B, 1jgg_B, 2hos_A, 4cyc_A, 1au7_A, 4xrs_G, 3l1p_A, 1le8_A, 7q3o_C, 1e3o_C, 2xsd_C, 7xrc_C, 8g87_X, 4qtr_D, 1du0_A, 4xrm_B, 6es3_K, 1o4x_A |
| Binding Motifs: | PH0095.1 sraaTTAATTAAwwamy |
| Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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