Transcription Factor
| Accessions: | T049051_1.02 (CISBP 1.02), Q8R4X9 (JASPAR 2024) |
| Names: | Glis2, T049051_1.02;, GLI-similar 2, GLIS2_MOUSE, Neuronal Krueppel-like protein, Zinc finger protein GLI5, Zinc finger protein GLIS2 |
| Organisms: | Mus musculus |
| Libraries: | CISBP 1.02 1, JASPAR 2024 2 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q8R4X9 |
| Notes: | experiment type:PBM, family:C2H2 ZF |
| Length: | 521 |
| Pfam Domains: | 224-246 Zinc-finger double domain 235-257 Zinc finger, C2H2 type 249-276 Zinc-finger double domain 263-287 Zinc finger, C2H2 type 293-317 Zinc finger, C2H2 type |
| Sequence: (in bold interface residues) | 1 MHSLDEPLDLKLSITKLRAAREKRERTLGVVRHHALHRELGLVDDSPAPGSPGSPPPGFL 60 61 LNPKFPEKVDGRFSAAPLVDLSLSPPSGLDSPNGSSSLSPECQGNGDLPPLPTAVDFQPL 120 121 RYLDGVPSSFQFFLPLGSGGALHLPASSFLPPPKDKCLSPELPLAKQLVCRWAKCNQLFE 180 181 LLQDLVDHVNDHHVKPEQDARYCCHWEGCARHGRGFNARYKMLIHIRTHTNEKPHRCPTC 240 241 NKSFSRLENLKIHNRSHTGEKPYVCPYEGCNKRYSNSSDRFKHTRTHYVDKPYYCKMPGC 300 301 HKRYTDPSSLRKHIKAHGHFVSHEQQELLQLRPPPKPPLPTPDSGSYVSGAQIIIPNPAA 360 361 LFGGPSLPGLPLPLPPGPLDLSALACGNGGGGGGGIGPGLPGSVLPLNLAKNPLLPSPFG 420 421 AGGLGLPVVSLLGGSAGSKAEGEKGRGSVPARVLGLEDHKTPLERTERSRSRPSPDGLPL 480 481 LPGTVLDLSTGNSAASSPEVLTPGWVVIPPGSVLLKPAVVN |
| Interface Residues: | 181, 183, 184, 187, 217, 218, 219, 220, 221, 222, 223, 224, 226, 227, 230, 245, 246, 247, 248, 249, 251, 252, 275, 276, 277, 278, 279, 280, 281, 282, 283, 285, 305, 306, 307, 308, 309, 310, 311, 312, 313 |
| 3D-footprint Homologues: | 5k5l_F, 5yel_A, 2i13_A, 7ysf_A, 1tf3_A, 8cuc_F, 5v3j_F, 3uk3_C, 2gli_A, 1g2f_F, 1tf6_A, 6ml4_A, 4x9j_A, 6u9q_A, 5ei9_F, 5kl3_A, 6wmi_A, 7eyi_G, 8h9h_G, 8gn3_A, 6e94_A, 5k5i_A, 7n5w_A, 1ubd_C, 2jpa_A, 7w1m_H, 6jnm_A, 7y3l_A, 2kmk_A, 8ssq_A, 5und_A, 8ssu_A, 1llm_D, 6blw_A, 5kkq_D, 1mey_C, 2drp_D, 2lt7_A, 7y3m_I, 6a57_A, 2wbs_A, 7txc_E, 1f2i_J, 5yj3_D, 4m9v_C |
| Binding Motifs: | PB0025.1 ywwsGACCCCCCayrd PB0129.1 wwTAttAwtAAAga M0393_1.02 rwgrGGGGTcy |
| Publications: | Badis G, Berger M.F, Philippakis A.A, Talukder S, Gehrke A.R, Jaeger S.A, Chan E.T, Metzler G, Vedenko A, Chen X, Kuznetsov H, Wang C.F, Coburn D, Newburger D.E, Morris Q, Hughes T.R, Bulyk M.L. Diversity and complexity in DNA recognition by transcription factors. Science (New York, N.Y.) 324:1720-3 (2009). [Pubmed] |
| Related annotations: | PaperBLAST |
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