DNA Binding Site

Accessions: ECK120011238 (RegulonDB 7.5)
Organisms: ECK12
Libraries: RegulonDB 7.5 1
1 Salgado H, Peralta-Gil M, Gama-Castro S, Santos-Zavaleta A, Muniz-Rascado L, Garcia-Sotelo JS, Weiss V, Solano-Lira H, Martinez-Flores I, Medina-Rivera A, Salgado-Osorio G, Alquicira-Hernandez S, Alquicira-Hernandez K, Lopez-Fuentes A, Porron-Sotelo L, Huerta AM, Bonavides-Martinez C, Balderas-Martinez YI, Pannier L, Olvera M, Labastida A, Jimenez-Jacinto V, Vega-Alvarado L, Del Moral-Chavez V, Hernandez-Alvarez A, Morett E, Collado-Vides J. RegulonDB v8.0: omics data sets, evolutionary conservation, regulatory phrases, cross-validated gold standards and more. Nucleic Acids Res. 2013 Jan 1;41(D1):D203-D213. [Pubmed]
Length: 42
Sequence: tctgaagttgAAACGTGATAGCCGTCAAACAAattggcactg
Binding TFs: ECK120004636 (Cyclic nucleotide-binding domain, Bacterial regulatory proteins, crp family, Crp-like helix-turn-helix domain)
Binding Motifs: CRP wtgtGAwyyasaTCACAwwwtt
Publications: Lange R., Hengge-Aronis R. Identification of a central regulator of stationary-phase gene expression in Escherichia coli. Mol Microbiol. 5(1):49-59 (1991). [Pubmed]

McCann MP., Fraley CD., Matin A. The putative sigma factor KatF is regulated posttranscriptionally during carbon starvation. J Bacteriol. 175(7):2143-9 (1993). [Pubmed]

Torres B., Porras G., Garcia JL., Diaz E. Regulation of the mhp cluster responsible for 3-(3-hydroxyphenyl) propionic acid degradation in escherichia coli. J Biol Chem. 278(30):27575-85. (2003). [Pubmed]

Friden P., Tsui P., Okamoto K., Freundlich M. Interaction of cyclic AMP receptor protein with the ilvB biosynthetic operon in E. coli. Nucleic Acids Res. 12(21):8145-60 (1984). [Pubmed]

Lloyd GS., Hollands K., Godfrey RE., Busby SJ. Transcription initiation in the Escherichia coli K-12 malI-malX intergenic region and the role of the cyclic AMP receptor protein. FEMS Microbiol Lett. 288(2):250-7 (2008). [Pubmed]

Plumbridge J., Kolb A. CAP and Nag repressor binding to the regulatory regions of the nagE-B and manX genes of Escherichia coli. J Mol Biol. 217(4):661-79 (1991). [Pubmed]

Zheng D., Constantinidou C., Hobman JL., Minchin SD. Identification of the CRP regulon using in vitro and in vivo transcriptional profiling. Nucleic Acids Res. 32(19):5874-93 (2004). [Pubmed]

Nishino K., Senda Y., Yamaguchi A. CRP regulator modulates multidrug resistance of Escherichia coli by repressing the mdtEF multidrug efflux genes. J Antibiot (Tokyo). 61(3):120-7 (2008). [Pubmed]

Hollands K., Lee DJ., Lloyd GS., Busby SJ. Activation of sigma-dependent transcription in Escherichia coli by the cyclic AMP receptor protein requires an unusual promoter organization. Mol Microbiol (2009). [Pubmed]

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