DNA Binding Site

Accessions: 3d70_B (3D-footprint 20231221), 3d71_M (3D-footprint 20231221), 3q3d_B (3D-footprint 20231221)
Organisms: Bacillus subtilis, strain 168
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Length: 23
Sequence: GACCCTCCCCTTAGGGGAGGGTC
Type: Heterodimer
Binding TFs: 3d70_A (MerR family regulatory protein, GyrI-like small molecule binding domain, MerR HTH family regulatory protein)
3d71_A (MerR family regulatory protein, GyrI-like small molecule binding domain, MerR HTH family regulatory protein)
3q3d_A (MerR family regulatory protein, GyrI-like small molecule binding domain, MerR HTH family regulatory protein)
Binding Motifs: 3d70_A CccT
3d71_A CCCT
3q3d_A CCCT
Publications: Newberry K.J, Huffman J.L, Miller M.C, Vazquez-Laslop N, Neyfakh A.A, Brennan R.G. Structures of BmrR-drug complexes reveal a rigid multidrug binding pocket and transcription activation through tyrosine expulsion. The Journal of biological chemistry 283:26795-804 (2008). [Pubmed]

Bachas S, Eginton C, Gunio D, Wade H. Structural contributions to multidrug recognition in the multidrug resistance (MDR) gene regulator, BmrR. Proceedings of the National Academy of Sciences of the United States of America 108:11046-51 (2011). [Pubmed]

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