DNA Binding Site
| Accessions: | 3ri4_E (3D-footprint 20231221), 3wts_D (3D-footprint 20231221), 3wtt_D (3D-footprint 20231221), 3wtt_I (3D-footprint 20231221), 3wtu_D (3D-footprint 20231221), 3wtu_I (3D-footprint 20231221), 3wtv_D (3D-footprint 20231221), 3wtv_I (3D-footprint 20231221), 3wtw_D (3D-footprint 20231221), 3wtw_I (3D-footprint 20231221), 3wtx_D (3D-footprint 20231221), 3wtx_I (3D-footprint 20231221), 3wty_D (3D-footprint 20231221), 3wty_I (3D-footprint 20231221), 3wu1_C (3D-footprint 20231221), 4l0y_C (3D-footprint 20231221), 4l0z_C (3D-footprint 20231221), 4l18_C (3D-footprint 20231221), 4l18_G (3D-footprint 20231221) |
| Organisms: | Homo sapiens, Mus musculus |
| Libraries: | 3D-footprint 20231221 1 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
| Length: | 15 |
| Sequence: | GAAGCCACATCCTCT |
| Type: | Heterodimer |
| Binding TFs: | 3wtx_C (Ets-domain) 3ri4_D (Ets-domain) 3wts_A (Runt domain) 3wts_C / 3wtt_C / 3wtu_C / 3wtv_C / 3wtw_C (Ets-domain) 3wtt_F / 3wtx_F / 3wty_F (Runt domain) 3wtu_F (Runt domain) 3wtv_F (Runt domain) 3wtw_F (Runt domain) 3wty_C (Ets-domain) 3wu1_A (Runt domain) 3wu1_B (Ets-domain) 4l0y_A (Runt domain) 4l0y_B (Ets-domain) 4l0z_B (Ets-domain) 4l18_B (Ets-domain) 4l18_E (Runt domain) 4l18_F (Ets-domain) |
| Binding Motifs: | 4l18_E AAGCCACA 3ri4_D CATCCT 3wts_A TGTGGctT 3wts_AC AGGATGTGGctt 3wts_C aGGa 3wtt_AC gCCACATCCt 3wtt_F TGTGGctT 3wtu_AC GCCACATCCT 3wtu_F AAGCCACA 3wtv_AC AGGATGTGGC 3wtv_F agCCACA 3wtw_AC GCCACATCCT 3wtw_F TGTGGctw 3wtx_AC GCCACATCCT 3wtx_F TGTGGcTt 3wty_AC GCCACATCCT 3wty_F TGTGGC 3wu1_A AAGCCACA 3wu1_AB AGGATGTGGCTT 4l0y_A AAGCCACA 4l0y_AB AAGCCACATCCT 4l0z_AB AAgCCACATCCT 4l0z_B aGGA 4l18_AB aGGATGTGGCTT 4l18_B aTCCt 4l18_EF AGGATGTGGCTT |
| Publications: | Babayeva N.D, Baranovskaya O.I, Tahirov T.H. Structural basis of Ets1 cooperative binding to widely separated sites on promoter DNA. PloS one 7:e33698 (2012). [Pubmed] Shiina M, Hamada K, Inoue-Bungo T, Shimamura M, Uchiyama A, Baba S, Sato K, Yamamoto M, Ogata K. A Novel Allosteric Mechanism on Protein-DNA Interactions underlying the Phosphorylation-Dependent Regulation of Ets1 Target Gene Expressions. Journal of molecular biology 427:1655-69 (2015). [Pubmed] Shrivastava T, Mino K, Babayeva N.D, Baranovskaya O.I, Rizzino A, Tahirov T.H. Structural basis of Ets1 activation by Runx1. Leukemia 28:2040-8 (2014). [Pubmed] |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.