DNA Binding Site

Accessions: 6wc2_E (3D-footprint 20231221), 6wc2_G (3D-footprint 20231221), 6wc2_K (3D-footprint 20231221), 6wc5_E (3D-footprint 20231221)
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Length: 21
Sequence: AAGCACTTTCTTAAAATAGTG
Type: Heterodimer
Binding TFs: 6wc2_N (Homeobox domain)
6wc2_D (SRF-type transcription factor (DNA-binding and dimerisation domain))
6wc2_M (Homeobox domain)
6wc2_O (Homeobox domain)
6wc5_I (Homeobox domain)
Binding Motifs: 6wc2_ABO CTAnnnnnGGAAAAngC
6wc2_CDM GCTAnnnnnaGAAAAngC
6wc2_D caCTA
6wc2_IJN CTAnnnnnnGAAAAnGC
6wc5_ABI CnCTttCTnnnnnnAG
Publications: Lei X, Zhao J, Sagendorf JM, Rajashekar N, Xu J, Dantas Machado AC, Sen C, Rohs R, Feng P, Chen L. Crystal Structures of Ternary Complexes of MEF2 and NKX2-5 Bound to DNA Reveal a Disease Related Protein-Protein Interaction Interface. J Mol Biol 432:5499-5508 (2020). [Pubmed]

Disclaimer and license

These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.