DNA Binding Motif

						

			
Accessions: FOXC1_DBD_3 (HumanTF 1.0), MA0032.2 (JASPAR 2024)

			
Names: FOXC1
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: monomeric; SELEX cycle: 3, HT-SELEX
Length: 11
Consensus: wAwRTMAAyAw
Weblogo: 
PSSM: P0      A      C      G      T
01   6452    772    304  12038      w
02  14324    728   4165   1386      A
03   7893   2008   2422  10596      w
04   4858    336  13631     51      R
05   2496   1652    390  18489      T
06  13117   5372     21     45      M
07  18489    108      0     57      A
08  18489     56    141    112      A
09    122   8782    165   9708      y
10  18489     27    433    184      A
11   6702   1558   1107  11787      w
Type: Heterodimer
Binding TFs: Q12948 (Fork head domain)
FOXC1_DBD (Fork head domain)
Q12948
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Berry FB, Skarie JM, Mirzayans F, Fortin Y, Hudson TJ, Raymond V, Link BA, Walter MA. FOXC1 is required for cell viability and resistance to oxidative stress in the eye through the transcriptional regulation of FOXO1A. Hum Mol Genet 17:490-505 (2008). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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