DNA Binding Motif

Accessions: 2h8r_B (3D-footprint 20231221)
Names: Hepatocyte nuclear factor 1-beta
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Hepatocyte Nuclear Factor 1b bound to DNA: MODY5 Gene Product
Length: 13
Consensus: TAATnntTcACCa
Weblogo:
PSSM: P0 A C G T
01 0 0 0 96 T
02 84 3 6 3 A
03 96 0 0 0 A
04 0 0 0 96 T
05 24 24 24 24 n
06 24 24 24 24 n
07 7 11 14 64 t
08 8 11 11 66 T
09 11 62 11 12 c
10 96 0 0 0 A
11 0 96 0 0 C
12 0 96 0 0 C
13 62 11 12 11 a
Binding TFs: 2h8r_B (Homeobox domain, Hepatocyte nuclear factor 1 (HNF-1), N terminus)
Binding Sites: 2h8r_E
2h8r_F
Publications: Lu P, Rha G.B, Chi Y.I. Structural basis of disease-causing mutations in hepatocyte nuclear factor 1beta. Biochemistry 46:12071-80 (2007). [Pubmed]

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