DNA Binding Motif

Accessions: 3rkq_AB (3D-footprint 20231221)
Names: Homeobox protein Nkx-2.5
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: NKX2.5 Homeodomain dimer bound to ANF-242 DNA
Length: 19
Consensus: TCAAGAGnnnnnCACTTCA
Weblogo:
PSSM: P0 A C G T
01 2 12 2 80 T
02 2 81 0 13 C
03 75 12 9 0 A
04 96 0 0 0 A
05 0 0 96 0 G
06 79 2 13 2 A
07 2 1 93 0 G
08 24 24 24 24 n
09 24 24 24 24 n
10 24 24 24 24 n
11 24 24 24 24 n
12 24 24 24 24 n
13 2 93 0 1 C
14 67 7 12 10 A
15 0 96 0 0 C
16 0 0 0 96 T
17 0 13 2 81 T
18 9 87 0 0 C
19 90 2 2 2 A
Type: Heterodimer
Binding TFs: 3rkq_A (Homeobox domain)
3rkq_B (Homeobox domain)
Binding Sites: 3rkq_C
3rkq_D
Publications: Pradhan L, Genis C, Scone P, Weinberg E.O, Kasahara H, Nam H.J. Crystal structure of the human NKX2.5 homeodomain in complex with DNA target. Biochemistry 51:6312-9 (2012). [Pubmed]

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