DNA Binding Motif

						

			
Accessions: NHLH1_full (HumanTF 1.0), MA0048.2 (JASPAR 2024)

			
Names: NHLH1
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: dimeric; SELEX cycle: 4, HT-SELEX
Length: 10
Consensus: cGCAGCTGCk
Weblogo: 
PSSM: P0      A      C      G      T
01    788   2166    181    111      c
02    461    179   2166    142      G
03      3   2166      0      0      C
04   2166      3      1      0      A
05      0    301   2166    114      G
06     96   2166    124      0      C
07      0      4      4   2166      T
08      2      4   2166      1      G
09    296   2166    102    350      C
10    308    736   2166   1489      k
Type: Heterodimer
Binding TFs: Q02575 (Helix-loop-helix DNA-binding domain)
NHLH1_full (Helix-loop-helix DNA-binding domain)
Q02575
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Brown L., Baer R. HEN1 encodes a 20-kilodalton phosphoprotein that binds an extended E-box motif as a homodimer. Mol. Cell. Biol. 14:1245-1255 (1994). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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