DNA Binding Motif

						

			
Accessions: NR2E1_full_1 (HumanTF 1.0), MA0676.1 (JASPAR 2024)

			
Names: NR2E1
Organisms: Homo sapiens, Mus musculus
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: monomeric; SELEX cycle: 4, HT-SELEX
Length: 9
Consensus: aaAAGTCAA
Weblogo: 
PSSM: P0      A      C      G      T
01   1118    244    191    401      a
02   1118     89    448    369      a
03   1118      1    101     19      A
04   1118      0     74      5      A
05     40      0   1118      8      G
06      0     58      0   1118      T
07     11   1118     12    112      C
08   1118      0      0      0      A
09   1118    131    117    247      A
Type: Heterodimer
Binding TFs: NR2E1_full (Ligand-binding domain of nuclear hormone receptor, Zinc finger, C4 type (two domains))
Q9Y466 (Ligand-binding domain of nuclear hormone receptor, Zinc finger, C4 type (two domains))
Q9Y466
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Yu RT, Chiang MY, Tanabe T, Kobayashi M, Yasuda K, Evans RM, Umesono K. The orphan nuclear receptor Tlx regulates Pax2 and is essential for vision. Proc Natl Acad Sci U S A 97:2621-5 (2000). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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