DNA Binding Motif

						

			
Accessions: SP8_DBD (HumanTF 1.0), MA0747.1 (JASPAR 2024)

			
Names: SP8
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: monomeric; SELEX cycle: 4, HT-SELEX
Length: 12
Consensus: rmCACgCCCmCy
Weblogo: 
PSSM: P0      A      C      G      T
01     52     27     78     10      r
02     54    113      0      4      m
03     25    167      0     13      C
04    133     33      1      2      A
05      7    167      1      5      C
06     25     37    167     39      g
07      5    167      6      2      C
08      2    167      3      0      C
09      0    167      4     15      C
10     90     77      6      3      m
11     13    167     21     39      C
12     31     52      1     82      y
Type: Heterodimer
Binding TFs: SP8_DBD (Zinc finger, C2H2 type, Zinc-finger of C2H2 type, Zinc-finger double domain, C2H2-type zinc finger)
Q8IXZ3 (Zinc finger, C2H2 type, Zinc-finger double domain, C2H2-type zinc finger)
Q8IXZ3
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Yokoyama KD, Pollock DD. SP transcription factor paralogs and DNA-binding sites coevolve and adaptively converge in mammals and birds. Genome Biol Evol : (2012;4(11):1102-17.). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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