DNA Binding Motif

						

			
Accessions: MLXIPL_full (HumanTF 1.0), MA0664.1 (JASPAR 2024)

			
Names: MLXIPL
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: dimeric; SELEX cycle: 3, HT-SELEX
Length: 10
Consensus: rtCACGTGat
Weblogo: 
PSSM: P0      A      C      G      T
01    345     31    220    113      r
02    126     28    133    468      t
03      0    448     11      0      C
04    411      0      2      5      A
05      2    452     12      0      C
06     20      2    735      0      G
07      0      0      3    562      T
08      0      0    727      0      G
09    356    110     87    113      a
10    138    181     53    442      t
Type: Heterodimer
Binding TFs: MLXIPL_full (Helix-loop-helix DNA-binding domain)
Q9NP71 (Helix-loop-helix DNA-binding domain)
Q9NP71
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Stoeckman AK, Ma L, Towle HC. Mlx is the functional heteromeric partner of the carbohydrate response element-binding protein in glucose regulation of lipogenic enzyme genes. J Biol Chem 279:15662-9 (2004). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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