DNA Binding Motif

Accessions: CLOCK_NHLH1_1 (HumanTF2 1.0)
Names: CLOCK_NHLH1
Organisms: Homo sapiens
Libraries: HumanTF2 1.0 1
1 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Notes: Site type: heterodimeric; Experiment type: CAP-SELEX
Length: 22
Consensus: cgCAGsTGckmcvrCACGTGbm
Weblogo:
PSSM: P0 A C G T
01 181 461 205 60 c
02 105 96 542 165 g
03 53 908 27 59 C
04 908 82 45 35 A
05 39 121 908 165 G
06 185 908 394 81 s
07 84 66 54 908 T
08 12 14 908 37 G
09 194 436 138 140 c
10 54 175 302 377 k
11 295 330 219 64 m
12 114 461 152 181 c
13 273 266 247 122 v
14 368 199 339 1 r
15 56 908 0 0 C
16 908 0 27 5 A
17 3 908 18 147 C
18 47 5 908 7 G
19 21 109 7 908 T
20 0 1 908 15 G
21 27 266 258 356 b
22 237 475 166 30 m
Type: Heterodimer
Binding TFs: CLOCK_TF1 / CLOCK_TF2 (Helix-loop-helix DNA-binding domain)
NHLH1_TF2 (Helix-loop-helix DNA-binding domain)
Publications: Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]

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