DNA Binding Motif

Accessions: MA1100.1 (JASPAR 2024)
Names: ASCL1
Organisms: Homo sapiens
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: ChIP-seq
Length: 13
Consensus: ssaGCAGCTGscs
Weblogo:
PSSM: P0 A C G T
01 1514 1815 2607 1116 s
02 1316 2808 2029 899 s
03 4367 692 1260 733 a
04 212 174 6639 27 G
05 28 6920 78 26 C
06 6820 61 75 96 A
07 21 280 6703 48 G
08 165 6343 523 21 C
09 55 69 72 6856 T
10 18 24 6987 23 G
11 334 2193 3523 1002 s
12 1477 2164 1718 1693 c
13 1533 1772 2478 1269 s
Type: Heterodimer
Binding TFs: P50553 (Helix-loop-helix DNA-binding domain)
P50553
Binding Sites: MA1100.1.1
MA1100.1.10
MA1100.1.11 / MA1100.1.8
MA1100.1.12
MA1100.1.13
MA1100.1.14
MA1100.1.15
MA1100.1.16
MA1100.1.17
MA1100.1.18
MA1100.1.19
MA1100.1.2
MA1100.1.20
MA1100.1.3
MA1100.1.4
MA1100.1.5
MA1100.1.6
MA1100.1.7
MA1100.1.9
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

Aydin B, Kakumanu A, Rossillo M, Moreno-Estellés M, Garipler G, Ringstad N, Flames N, Mahony S, Mazzoni EO. Proneural factors Ascl1 and Neurog2 contribute to neuronal subtype identities by establishing distinct chromatin landscapes. Nat Neurosci 22:897-908 (2019). [Pubmed]

Disclaimer and license

These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.