DNA Binding Motif

						

			
Accessions: POU3F2_DBD_2 (HumanTF 1.0), MA0787.1 (JASPAR 2024)

			
Names: POU3F2
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, JASPAR 2024 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: Site type: monomeric; SELEX cycle: 3, HT-SELEX
Length: 12
Consensus: wTATGCwAATka
Weblogo: 
PSSM: P0      A      C      G      T
01    591     61    171    700      w
02    163     65     40   1292      T
03   1292     16     25      0      A
04     28     30     12   1292      T
05     19      9   1292     60      G
06     68   1292    153    372      C
07    688      4      1    604      w
08   1292     16     32     45      A
09   1292      6      0     13      A
10     63     19     28   1292      T
11    137    165    452    840      k
12   1292    262    261    562      a
Type: Heterodimer
Binding TFs: POU3F2_DBD (Homeobox domain, Pou domain - N-terminal to homeobox domain)
P20265 (Homeobox domain, Pou domain - N-terminal to homeobox domain)
P20265
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Rhee J. M., Gruber C. A., Brodie T. B., Trieu M., Turner E. E. Highly cooperative homodimerization is a conserved property of neural POU proteins. J. Biol. Chem. 273:34196-34205 (1998). [Pubmed]

	
			


			

				

				
				
				
				

			

			

		

	
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