DNA Binding Motif

Accessions: 6wc5_CDN (3D-footprint 2022-04-03)
Names: Myocyte-specific enhancer factor 2B
Organisms: Homo sapiens
Libraries: 3D-footprint 2022-04-03 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Description: Crystal Structure of a Ternary MEF2B/NKX2-5/myocardin enhancer DNA Complex
Length: 14
Consensus: CTTTCynnnnnTAG
Weblogo:
PSSM: P0 A C G T
01 6 76 12 2 C
02 0 0 0 96 T
03 0 0 7 89 T
04 0 6 0 90 T
05 0 96 0 0 C
06 12 51 6 27 y
07 24 24 24 24 n
08 24 24 24 24 n
09 24 24 24 24 n
10 24 24 24 24 n
11 24 24 24 24 n
12 12 8 6 70 T
13 90 0 6 0 A
14 0 0 96 0 G
Type: Heterodimer
Binding TFs: 6wc5_C / 6wc5_D (SRF-type transcription factor (DNA-binding and dimerisation domain))
6wc5_N (Homeobox domain)
Binding Sites: 6wc5_G
6wc5_H
Publications: Lei X, Zhao J, Sagendorf JM, Rajashekar N, Xu J, Dantas Machado AC, Sen C, Rohs R, Feng P, Chen L. Crystal Structures of Ternary Complexes of MEF2 and NKX2-5 Bound to DNA Reveal a Disease Related Protein-Protein Interaction Interface. J Mol Biol 432:5499-5508 (2020). [Pubmed]

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